Role of growth hormone and prolactin in regulating T-dependent immune responses and macrophage activation in aged rats

Animals and humans become increasingly susceptible to infectious, arthritic, and neoplastic diseases during aging. Both growth hormone (GH) and prolactin (PRL) are important in normal immune function, and they also augment immune responses in immunocompromised and aged individuals. We previously showed that GH and PRL treatment of aged rats resulted in fully regenerated thymus glands and enhancement of certain T cell-mediated responses. The studies described here utilized primarily the aged rat model to further examine the effects of GH and PRL upon certain T cell, natural killer cell (NK), and macrophage-mediated responses.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Davila, Donna Remley

Contributors dc:contributor

• Kelley, Keith W.

• Biology, General
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1989 Davila, Donna Remley

Language dc:language

eng

Identifier

AAI8916236
(UMI)AAI8916236

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20957