Effects of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels in prepubertal female rats

A 2-day short-term bioassay, using prepubertal female Sprague-Dawley rats, was developed to study effects of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels. Three approaches have been used to study the multiple effects of PCB mixtures: (1) environmental mixtures (soil, dust and air samples) collected from the Sangamo landfill site were directly examined and the chemical compositions of these mixtures were analyzed; (2) the soil extract from the Sangamo landfill site was fractionated by alumina-charcoal column chromatography, the effects of this fraction were tested, and the results were compared with the effects of the original soil extract; (3) a combination of specific chlorobiphenyls (CBs) (2,3,3$\sp\prime,4\sp\prime$,6-pentachlorobiphenyl (CB 110) plus 3,3$\sp\prime,4,4\sp\prime$,5-pentachlorobiphenyl (CB 126)) and a synthetic mixture which contained 95.5% CB 110, 0.5% CB 126 and 4% two unidentified pentaCBs were also examined. In addition, the effects of 3 environmentally abundant di-ortho CBs (2,2$\sp\prime,4,4\sp\prime,5,5\sp\prime$-hexachlorobiphenyl (CB 153), 2,2$\sp\prime$,5-trichlorobiphenyl (CB 18) and CB 110) were examined.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Biosciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Li, Mei-Hui

Contributors dc:contributor

• Hansen, Larry G.

• Health Sciences, Toxicology
• Environmental Sciences

Statement dc:rights

• Copyright 1996 Li, Mei-Hui

Language dc:language

eng

Identifier

AAI9625157
(UMI)AAI9625157

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20836