Biologically active compounds from a clam and a tunicate

Part I. Isolation and characterization of sphingosine analogs from the clam Spisula polynyma. Extracts of the Stimpson surf clam, Spisula polynyma, were found to cause a distinct alteration of the morphology of L1210 murine leukemia cells in which the compounds develop sharp points, usually located opposite to each other. The compounds responsible for this activity, spisulamines 285, 299 and 313 were isolated and characterized along with sphingosine and several of its analogs. The spisulamines were determined to be sphingoid-type bases. Specifically, spisulamine 285 is $(2S\sp{\*},3R\sp{\*})$-2-amino-3-octadecanol, while the other spisulamines are higher homologs. These compounds were also found to be cytotoxic to L1210 cells.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Fregeau, Nancy Louise

Contributors dc:contributor

• Rinehart, Kenneth L., Jr.

• Chemistry, Organic
• Chemistry, Pharmaceutical

Statement dc:rights

• Copyright 1992 Fregeau, Nancy Louise

Language dc:language

eng

Identifier

9780591636017
AAI9812827
(UMI)AAI9812827

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20793