Tetrahydrochrysene and cyclofenil derivatives as fluorescent probes of the estrogen receptor

We prepared tetrahydrochrysene (THC) derivatives IIIb-e as the first fluorescent estrogens, designed to satisfy the criteria for a direct fluorometric assay of the estrogen receptor in cells. The preparation of unsymmetrical chrysenes IIIb-e, containing ketone, ester, amide, and nitrile groups, was achieved efficiently under mild conditions, by the palladium-mediated arylcarbonylation of intermediate 15 as the key step. However, the RBA of compounds IIIb-e (RBA = 15-40%) is still sufficient for them to be studied as fluorescent probes for the estrogen receptor.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Hwang, Kwang Jin

Contributors dc:contributor

• Katzenellenbogen, John A.

• Chemistry, Organic
• Chemistry, Pharmaceutical

Statement dc:rights

• Copyright 1991 Hwang, Kwang Jin

Language dc:language

eng

Identifier

AAI9136623
(UMI)AAI9136623

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20726