T-cell receptor diversity of various antigen-specific T cells

T cells recognize foreign antigen through a heterodimeric αβ T-cell receptor (TCR). The TCR ligand is a peptide bound to a membrane-bound protein coded by the major histocompatibility complex (MHC) locus. Like immunoglobulins, the TCR repertoire is diverse because both the α and β chains are coded by multiple genes that undergo rearrangement. The general goal of this study was to determine the diversity of TCRs from specific T cell populations, including T cells that are reactive with multiple ligands and TCRs that are reactive with a single peptide/MHC protein complex.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Tjoa, Benjamin Alan

Contributors dc:contributor

• Kranz, David M.

• Biology, Molecular
• Chemistry, Biochemistry
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1994 Tjoa, Benjamin Alan

Language dc:language

eng

Identifier

AAI9416444
(UMI)AAI9416444

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20614