DNase 1 hypersensitive sites in rabbit cytochrome P-450IIC subfamily genes and binding of liver nuclear proteins

Cytochrome P450 genes are expressed in different tissues and show a heterogenous response upon the treatment with various inducers. Increased levels of mRNAs of the P450IIC genes after phenobarbital treatment is primarily due to an increase in the rate of transcription. The frequency of transcriptional initiation determines the level of transcription and this event is mainly achieved by the interaction of trans-acting regulatory proteins with cis-acting DNA elements of a gene. Therefore, to elucidate the mechanism of gene regulation of the P450IIC genes, identification of cis-acting regulatory elements in the P450IIC genes and the corresponding trans-acting factors is required.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Molecular Physiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Ahn, Jongsook Kim

Contributors dc:contributor

• Kemper, Byron W.

• Biology, Molecular
• Biology, Animal Physiology

Statement dc:rights

• Copyright 1991 Ahn, Jongsook Kim

Language dc:language

eng

Identifier

AAI9136526
(UMI)AAI9136526

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20553