Structure-function and gene analysis of anti-DNA autoantibodies from BW mice

Anti-DNA autoantibodies in both autoimmune murine strains and in humans have been implicated in the pathogenesis of the autoimmune disorder SLE (systemic lupus erythematosus). The primary goal was to examine the structural features of monoclonal anti-DNA autoantibodies derived from the BW mouse autoimmune strain in order to: (1) determine the IgV$\sb{\rm H}$ and V$\sb{\rm L}$ gene repertoire encoding these autoantibodies, and (2) define components of the antibody active-site involved in DNA binding.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Smith, Rodger Getting

Contributors dc:contributor

• Voss, Edward W., Jr.

• Biology, Molecular
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1990 Smith, Rodger Getting

Language dc:language

eng

Identifier

AAI9021758
(UMI)AAI9021758

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20450