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University of Illinois at Urbana-Champaign
Apoptosis and porphyrin biosynthesis by a photodynamic chemotherapeutic
Abstract
dc:descriptionδ-Aminolevulinic acid (ALA) causes transformed cells to accumulate protoporphyrin IX (Proto). Subsequent exposure to light in vitro causes intracellular Proto to initiate formation of singlet oxygen molecules, leading to self-destruction. This photo-activated destruction by ALA is enhanced by addition of the tetrapyrrole modulator 1,10-phenanthroline (Oph), by enhancing Proto accumulation. We determined the efficacy and intracellular localization and biosynthesis of Proto, and the role of apoptosis in ALA- and Oph-mediated cell death of transformed cells.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Animal Sciences
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Rebeiz, Natalie
- Contributors dc:contributor
-
- Kelley, Keith W.
Subjects
dc:subject × 3Rights
dc:rights- Statement dc:rights
-
- Copyright 1996 Rebeiz, Natalie
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
-
9780591088342
AAI9702649
(UMI)AAI9702649 - OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/20363