Catalytic site mutagenesis of cytochrome P450 6B1v1

Cytochromes P-450 form a large superfamily of heme-containing monooxygenases that are found in species ranging from bacteria to insects, plants, and mammals. In insects, P-450s have several functional roles, including growth, development, feeding, resistance to pesticides, and tolerance to plant toxins. Cytochrome P-450 6B1v1 (CYP6B1v1) is a membrane-bound P-450 derived from larvae of the black swallowtail butterfly, Papilio polyxenes, in midgut microsomes. It predominantly involves the detoxification or metabolism of xanthotoxin, a linear furanocoumarin, with very little capability to metabolize angelicin, an angular furanocoumarin. Both furanocoumarins are naturally occurring secondary plant metabolites with the highly phototoxic property.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Pookanjanatavip, Manee

Contributors dc:contributor

• Sligar, Stephen G.

• Biology, Molecular
• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1996 Pookanjanatavip, Manee

Language dc:language

eng

Identifier

9780591088250
AAI9702640
(UMI)AAI9702640

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20144