An investigation into morphological and biochemical abnormalities in the central nervous system of the mutant mouse tottering

The mutant mouse tottering carries an autosomal recessive single gene mutation on chromosome 8 that produces three distinct neurological disorders shortly before weaning: petit mal or absence-like seizures, ataxia and intermittent movement disorders. The majority of the research on the mutant mouse tottering has concentrated on investigating the petit mal component of the neurological triad while overlooking the significant motor behavior abnormalities. This dissertation compared the morphology of developing and adult cerebella and the distribution patterns of calcium binding proteins throughout the motor systems of the brain, in two related murine mutants (tottering (tg/tg) and tottering/leaner ($tg/tg\sp{\rm la}$)) and normal age-matched mice.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Neuroscience

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Isaacs, Krystyna Renata

Contributors dc:contributor

• Abbott, Louise C.

• Biology, Anatomy
• Biology, Neuroscience

Statement dc:rights

• Copyright 1993 Isaacs, Krystyna Renata

Language dc:language

eng

Identifier

AAI9314885
(UMI)AAI9314885

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/19676