Model systems for the retargeting of T cell-mediated immunity to tumor antigens

B cells and T cells are involved in the response against foreign antigens. Specificity of B cells is determined by antibodies while the specificity of T cells is determined by similar proteins called T-cell receptors. One function of T cells is surveillance against tumor cells. Progressing tumors have escaped T cell surveillance, but the immune system could still be effective if the T cell immune response could be retargeted against the tumor. A strategy for accomplishing this is the construction of a bispecific antibody which binds a tumor cell antigen and a T-cell receptor, bringing the T cell into contact with the tumor cell and activating the T cell to destroy the tumor cell.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Wilson, Erik Robert

Contributors dc:contributor

• Kranz, David M.

• Chemistry, Biochemistry
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1994 Wilson, Erik Robert

Language dc:language

eng

Identifier

AAI9512597
(UMI)AAI9512597

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/19561