University of Illinois at Urbana-Champaign
Developmental regulation of the alpha(7) integrin chain during myogenesis
Abstract
dc:descriptionThe α7β1 integrin is the major laminin receptor on skeletal muscle cells. Its expression is developmental regulated during myogenesis. Not only is the expression of α7 transcripts increased upon myogenic differentiation, differential splicing of transcripts is also observed at that time. This differential splicing of α7 transcripts results in three different mRNAs which encode α7 chains with three different cytoplasmic domains. The α7B form is expressed both in replicating myoblasts and in differentiated myotubes and adult fibers. The α7A and α7C forms are only detected after myoblasts have undergone terminal differentiation. These three isoforms contain both a common as well as distinct potential phosphorylation sites and these may function in alternate signal transduction events.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Microbiology
- Grantor
- University of Illinois at Urbana-Champaign
- Date dc:date
- 10000-01-01
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Wang, Weigwang
- Contributors dc:contributor
-
- Kaufman, Stephen J.
Subjects
dc:subject × 2Rights
dc:rights- Statement dc:rights
-
- Copyright 1995 Wang, Weigwang
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
-
AAI9624531
(UMI)AAI9624531 - OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/19525