Synthesis and evaluation of fluorine-18 labeled androgens as in vivo imaging agents for prostatic cancer using PET

In order to develop androgen receptor (AR) based probes for in vivo imaging of prostatic cancer using positron emission tomography (PET), four pairs of 16β- and 16α-fluoro androgens, as well as two 20-fluoro androgens have been synthesized. The fluorination was achieved mainly by nucleophilic fluoride displacement of a triflate or a spirocyclic sulfate precursor, prepared by multistep synthesis.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Liu, Aijun

Contributors dc:contributor

• Katzenellenbogen, John A.

• Chemistry, Organic
• Chemistry, Pharmaceutical
• Health Sciences, Radiology
• Chemistry, Nuclear

Statement dc:rights

• Copyright 1991 Liu, Aijun

Language dc:language

eng

Identifier

AAI9210898
(UMI)AAI9210898

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/19453