Biophysical studies of chromatin folding and unfolding

Chromatin, the building material of chromosomes, is folded and unfolded by several levels, providing a physical basis of coordinated DNA functions in eukaryotic cells. Chromatin folding is started with a linear long string of nucleosomes, connected by segments of DNA called linker DNA. Further folding forms the higher order structure, 30-nm fibers in which form most DNA in interphase nuclei is maintained. Nucleosomes arrange helically at this level, but the connectivity of the nucleosomes is unclear, and depends on the structure of linker DNA.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Yao, Jian

Contributors dc:contributor

• Widom, Jonathan

• Biology, Molecular
• Chemistry, Biochemistry
• Chemistry, Physical

Statement dc:rights

• Copyright 1991 Yao, Jian

Language dc:language

eng

Identifier

AAI9211048
(UMI)AAI9211048

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/19346