Catheter for endoscopic magnetomotive optical coherence tomography

In this thesis, a catheter design is proposed for endoscopic magnetomotive optical coherence tomography (MM-OCT). Magnetomotive optical coherence tomography is a novel technique which uses targeted magnetic contrast agents for contrast enhancement of OCT imaging. In MM-OCT, microspheres and magnetic nanoparticles (MNPs) are introduced into tissue and an electromagnet is used to generate a small modulated magnetic field within the tissue during OCT imaging. The magnetic field will introduce mechanical displacement of the MNPs, which can be detected, and the MM-OCT signal can be measured. The current bench-top set-up does not allow for in vivo MM-OCT imaging because the magnetic field is provide by a solenoid with an outer diameter of ~18 mm and an axial thickness of ~9 mm. A magnetomotive catheter design was developed by wrapping small coil around the distal end of a standard OCT catheter to combine the novel MM-OCT technology and catheter-based OCT. The coil has a small size while providing a local magnetic field for MM-OCT imaging. This magnetomotive catheter will enable investigations of in vivo magnetomotive contrast enhancement from the magnetic agents used in MM-OCT imaging.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Nuclear Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Li, Di

Contributors dc:contributor

• Boppart, Stephen A.

• Optical Coherence Tomography
• Catheter
• Magnetomotive optical coherence tomography (OCT)

Statement dc:rights

• Copyright 2010 Di Li

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/18621

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/18621