Towards extending coarse-grained circuit-host modeling to complex environments

Over the last two decades, synthetic biology has emerged as a critical toolset for genetic engineering. Synthetic gene circuits have been engineered for a variety of uses from functional modules to increasing biosynthetic yield. After decades of showing their potential in labs, synthetic circuits are about to make the leap into complex environments. Recent advances have shown that a mechanistic, coarse-grained approach can give fundamental insight into how synthetic circuits interact with their host cells, though how this model can be applied in complex environments remains an open question. In this thesis, I will discuss how an extension of this coarse-grained model can describe circuit behavior in complex environments through mechanistic modeling of chloramphenicol and nutrient stress.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biophysics & Quant Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2020

Author dc:creator

• Sickle, Jordan

Contributors dc:contributor

• Lu, Ting

• Synthetic Biology
• Mathematical Modeling

Statement dc:rights

• Copyright 2019 Jordan Sickle

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/106484

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/106484