Glutathione utilization in lactobacillus fermentum CECT 5716

Glutathione, a tripeptide antioxidant, has recently been shown to be either utilized or synthesized by gram-positive bacteria, such as Lactic Acid Bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding glutathione in Lactobacillus fermentum CECT 5716 is characterized. We demonstrate that L. fermentum CECT 5716 has a better survival rate in the presence of glutathione under both oxidative and metal stress. As L. fermentum CECT 5716 does not possess the ability to synthesize glutathione, it shows the ability to uptake both reduced and oxidized glutathione from the environment, regenerate reduced glutathione from oxidized glutathione, and perform secretion of glutathione to the environment.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Food Science & Human Nutrition

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2018

Author dc:creator

• Surya, Agustian

Contributors dc:contributor

• Miller, Michael J.

• Glutathione, Lactobacillus fermentum, Oxidative stress, Metal Stress, Lactic Acid Bacteria

Statement dc:rights

• Copyright 2018 Agustian Surya

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/101717

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/101717