Bioinspired Mo/W-Oxo Complexes: Synthesis and Reactivity Across Multiple Ligand Scaffolds

Selective C–H bond functionalization remains a major challenge in synthetic chemistry, while molybdenum and tungsten-containing enzymes carry out difficult oxidative transformations with remarkable efficiency and selectivity under mild conditions. Among these, the xanthine oxidoreductase family provides an important model for understanding how high-valent metal-oxo centers and sulfur- rich ligand environments work together to control structure and reactivity. Molybdenum and tungsten complexes were investigated as bioinspired models of these active sites, with particular focus on ligand platforms designed to capture key structural features of the enzymatic coordination environment. The study focuses on how metal identity and ligand environment shape oxo stability, electronic structure, and reactivity, especially in systems where the strong tungsten-oxo bond restricts chemical transformation. Together, these studies provide insight into the structural and chemical factors that govern Mo/W oxo reactivity and contribute to the broader design of functional biomimetic systems for oxidation chemistry.

Author dc:creator

• - Ira (24400283)

• Chemistry
• Inorganic

Statement dc:rights

• In Copyright
• Open Access after 2028-05-01

DOI dc:identifier

https://doi.org/10.25417/uic.32995337.v1

OAI identifier oai:identifier

oai:figshare.com:article/32995337