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Showing 1 to 20 of 77 for “"Synthetic Chemistry"”.
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Heavy-metal-free colloidal nanocrystal heterostructures – synthetic chemistry and growth mechanisms
… Therefore, a better understanding of the synthetic chemistry and the growth mechanisms for heavy-metal-free nanocrystal heterostructures is critical before their commercialization potential becomes reality. Here, we have developed novel synthetic strategies to achieve the anisotropic …
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Acoustic emulsions of liquid, near-critical carbon dioxide and water : application to synthetic chemistry through reaction engineering
Supervised by The need to eliminate hazardous solvents, such as methanol, toluene, and dichloromethane, in specialty and pharmaceutical chemical synthesis applications has motivated the development of alternative approaches. Because of its environmental compatibility, low cost, and favorable …
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Carbon-nitrogen bond-forming reactions in supercritical and expanded-liquid carbon dioxide media : green synthetic chemistry with multiscale reaction and phase behavior modeling
… CO2-based processes. Amine chemistry in CO2-based media was complicated by the facility of nucleophilic amines to react with carbon dioxide to form carbamic acids, which sometimes interfered with desired reaction pathways. Experimental observations and a complimentary ab …
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Synthesis of pyridines and azaindoles via Diels-Alder reactions of tosyl cyanide with vinyl- and heteroarylallenes
… pyridines is an ongoing goal of modem synthetic chemistry. Part I of this thesis describes a new synthetic strategy for the synthesis of highly substituted pyridines and azaindoles involving Diels-Alder reactions of vinyl- and heteroarylallenes with tosyl cyanide. The synthetic …
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Synthetic Studies in the Formation of Nitrogen Containing Compounds: From Simple Amines to Complex Natural Products
… compounds are important building blocks in synthetic chemistry. Not only for biologically active small molecules but in more complex biologically active natural products. Having novel methods to access these types of molecules is an important undertaking in synthetic chemistry. Then striving …
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Planning And Interpretation Of Late Stage Functionalisation Reactions
… efficiency for every step of the process. Synthetic chemistry delivers drug candidates in a fast and efficient manner. Late stage functionalisation (LSF) is poised to accelerate the process by making chemical synthesis modular so most of the molecules are assembled via standard protocols. …
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Investigation of the Discoipyrroles and Other Marine Bacteria Derived Natural Products
… canonically celebrated as biomedical tools or synthetic chemistry feats. Discovery of new chemical compounds has benefited from the study of natural product biosynthesis, or the methods by which they are constructed. Additionally, these studies have advanced the fields of ecology, industrial …
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Design and implementation of an automated reconfigurable modular flow chemistry synthesis platform
Synthetic chemistry has been the driving force behind advances in pharmaceuticals, agricultural chemicals to advanced materials; however, these fields have struggled with a slow pace of discovery, limited reproducibility, and difficulty scaling promising new molecules. Current organic chemistry …
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Bioinspired Mo/W-Oxo Complexes: Synthesis and Reactivity Across Multiple Ligand Scaffolds
… functionalization remains a major challenge in synthetic chemistry, while molybdenum and tungsten-containing enzymes carry out difficult oxidative transformations with remarkable efficiency and selectivity under mild conditions. Among these, the xanthine oxidoreductase family provides an …
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Microfluidic synthesis of colloidal nanomaterials
… synthesis of nanomaterials. Standard bench-scale synthetic chemistry techniques often involve non-uniform spatial and temporal distributions of concentration and temperature, and are not readily scalable. Photolithography-based microfabrication enables the application of classical techniques of …
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Development and optimization of photoredox-mediated methine epimerization
Reactions that edit the stereochemistry of individual atoms are enabling tools in synthetic chemistry. The Wendlandt lab has developed a sequential H-atom abstraction and donation strategy to synthesize rare sugars from biomass platform molecules such as D-glucose. Efforts to apply this strategy to …
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Synthesis, structure, and reactivity of polyoxovanadates in nonaqueous media
Exploration of the nonaqueous chemistry of polyoxovanadates was initiated by studying the following reaction: x $\rm H\sb3V\sb{10}O\sb{28}\sp{3-}$ + y OH$\sp-$ $\to$ 10 $\rm H\sb nV\sb xO\sb m\sp{z-}$ + (y-n) H$\sb2$O involving the addition of (TBA)(OH) to ($\rm H\sb3V\sb{10}O\sb{28}$)(TBA)$\sb3$ …
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Synthesis and characterization of conducting polymer actuators
… materials, spanning scientific disciplines from synthetic chemistry to materials and mechanical engineering. As such, the topics of synthesis and characterization of new conducting polymers are discussed, highlighting developments in techniques and instrumentation. Actuation in …
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Enabling Starting Material-Oriented Strategies in Computer-Aided Synthesis Planning With a Bidirectional Search Algorithm
… starting materials, is a fundamental task in synthetic chemistry. Current computational search methods assume the sufficiency of reaching arbitrary building blocks but fail to address the common real-world constraint where the use of specific starting materials is desirable. To this end, this …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
… have applications in medicinal, and materials chemistry, and also as cross-coupling agents in synthetic chemistry. Boronic acids often function as inhibitors for various enzymes due to their unique electronic and physicochemical properties. B-hydroxy-1,2-oxaborolanes (benzoboroxoles) are a …
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Structural Studies on the Regulation of Sporulation in Bacillus and Antibiotic Sulfation
… and the techniques of X-ray crystallography, synthetic chemistry, and protein semisynthesis, we have: (1) Solved the X-ray crystal structure of a Geobacillus stearothermophilus sporulation histidine kinase in complex with an inhibitor of the kinase reaction (Chapter 2). (2) Developed an …
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Ordered arrays of nanocrystals : synthesis, properties and applications
… in conjunction with inorganic and organic synthetic chemistry for the controlled synthesis of ordered arrays of nanocrystals. A unique attribute of this technique is it combined themes one and three, aforementioned, into a single step. First, uniform arrays of various mono- and …
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Synthesis and Biosynthesis of Polyketide Natural Products
… of a large and broad chemical spectrum, synthetic organic chemistry and biochemistry have found in the last two decades a fertile common ground in the area pertaining to the biosynthesis of natural products. Both disciplines remain indispensable in providing unique solutions on numerous …
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Synthesis and properties of transition-metal arsenide nanostructures: from superparamagnetism to superconductivity
… and increased packing efficiency in devices. Synthetic chemistry skills and nanofabrication techniques like wet chemistry, electrodeposition, solvothermal, hydrothermal and lithography, are extremely useful for creating nanostructures of these functional materials. This is a challenging task …
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