In Vitro Study Comparing Treatments for Incipient Enamel Lesion Remineralization

Purpose: This study compared the remineralization efficacy of Icon™, 3M™ Varnish™ 5% Sodium Fluoride White Varnish (FV), and 38% Silver Diamine Fluoride (SDF; Advantage Arrest™) on enamel surfaces affected by incipient caries lesions. Methods: Caries-free permanent teeth, extracted for orthodontic or surgical purposes, were obtained from the Pediatric Dentistry Department at UIC College of Dentistry. Enamel samples (4 mm x 5 mm) were prepared, frozen, and subjected to baseline microhardness testing. Samples were randomized into four groups (n=5/group): Icon, FV, SDF, and a control group. Artificial caries lesions were induced and treated per manufacturers’ instructions. Samples were immersed in a saliva-like remineralization solution for seven days, and post-treatment microhardness was assessed at 20 μm intervals to a depth of 200 μm. Statistical analyses included ANOVA with Tukey-Kramer post hoc tests and Generalized Estimating Equation (GEE) modeling. Results: SDF demonstrated the lowest microhardness values, with a mean of 147.24 (SD: 39.76) at 100 μm, significantly lower than FV (276.54; SD: 33.72), Icon (254.59; SD: 30.18), and the control (253.19; SD: 36.16). FV and Icon showed significantly higher microhardness, indicating superior enamel strengthening compared to SDF. No significant differences were found between FV and Icon. Conclusions: When managing incipient caries, all three materials are effective options for addressing early caries lesions. However, FV and Icon provided superior remineralization and surface hardening when compared to SDF.

Author dc:creator

• Aliyah Wilson (22481695)

• Pediatric Dentistry

Statement dc:rights

• In Copyright

DOI dc:identifier

https://doi.org/10.25417/uic.30424960.v1

OAI identifier oai:identifier

oai:figshare.com:article/30424960