Desert Hedgehog is a Mammal-Specific Gene Expressed During Testicular and Ovarian Development in a Marsupial

<h1>Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH signals through the patched (PTCH) receptors 1 and 2. Here we examine the expression and protein distribution of DHH, PTCH1 and PTCH2 in the developing testes of a marsupial mammal (the tammar wallaby) to determine whether DHH signalling is a conserved factor in gonadal development in all therian mammals.</h1>

Name thesis:degree_name

Master of Science

Discipline thesis:degree_discipline

Genetics and Genomics

Year dc:date.available

2012

Author dc:creator

• O'Hara, William A

Contributors dc:contributor

• Rachel O'Neill, Ph.D.; Craig Nelson, Ph.D.
• Andrew J. Pask, Ph.D.

• Sex determination
• sexual differentiation
• gene expression
• marsupial
• Macropus eugenii.

Repository record dc:identifier

https://digitalcommons.lib.uconn.edu/gs_theses/215

OAI identifier oai:identifier

oai:digitalcommons.lib.uconn.edu:gs_theses-1247