Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Morphogen"”.
-
Formation of morphogen gradients
Morphogens are signaling molecules that play a key role in animal development. They spread from a restricted source into an adjacent target tissue forming a concentration gradient. The fate of cells in the target tissue is determined by the local concentration of such morphogens. Morphogen …
-
Regulation of morphogen signalling during neural patterning in the Xenopus embryo
Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts …
-
Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
… These findings shed light on the mechanism of morphogen biogenesis in Hedgehog and Wnt signaling pathways and could pave the way for the development of new therapeutics to target these pathways.
-
Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… endoderm, and ectoderm are specified. Bone morphogenetic protein 4 (BMP4), secreted from the extraembryonic ectoderm is required for gastrulation to start whereby it activates downstream signaling molecules wingless inhibitor 3 (WNT3) and Nodal in a concentration dependent manner to specify …
-
NOGGIN Transport in a Model Human Epiblast
… In this work, I interrogate the interplay of the morphogen/inhibitor pair BMP4/NOGGIN within our model of the polarized human embryonic disc. Here, I report the surprising discovery that in human epiblasts, NOGGIN and BMP4 were selectively secreted into opposite sides of the polarized epithelium, …
-
Self-organized Pattern Formation using Engineered Bacteria
… the vast majority of these mechanisms invoke morphogen gradients, which are either predefined or generated as part of the patterning processes. However, using E. coli programmed by a simple synthetic gene circuit, I demonstrate here the generation of robust, self-organized ring patterns of …
-
QUANTITATIVE MODELING OF SCALING OF PATTERNS AND RECEPTOR SIGNALING IN MORPHOGENESIS
… guide a number of those processes are known as morphogens. Developing cells sense their respective positional information from a graded morphogen profile, and differentiate into patterns. Remarkably, patterns are highly robust and reproducible among species, and the underlying mechanisms …
-
The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
… Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show that the …
-
Role of endocytic trafficking during Dpp gradient formation
Morphogens are secreted signalling molecules that are expressed in restricted groups of cells within the developing tissue. From there, they are secreted and travel throughout the target field and form concentration gradients. These concentration profiles endow receiving cells with positional …
-
Fate, Phases, and Form in Vertebrate Organ Morphogenesis-Uncovering a Role of Morphogenesis at the Supracellular Scale
… supracellular structures independent of any morphogen activities. This challenges the classic chemical model where a morphogen pre-pattern dictates follicle patterning, prompting the question of what functional roles morphogens serve. found that morphogens enable the creation of membrane-less …
-
Establishment of retinoic acid gradients in the early development of Xenopus laevis
Retinsäure (RA) ist ein wichtiges Morphogen, das viele biologische Prozesse reguliert, einschließlich der Entwicklung des zentralen Nervensystems (ZNS). Die Synthese von RA aus Vitamin A (Retinol) läuft in zwei Schritten ab, wobei die zweite Reaktion- katalysiert von Retinal-Dehydrogenasen …
-
Desert Hedgehog is a Mammal-Specific Gene Expressed During Testicular and Ovarian Development in a Marsupial
… signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH signals through the patched (PTCH) receptors 1 and 2. Here we examine the expression and …
-
Vergleich der Osteoinduktivität von rhBMP-2 und rhBMP-2-Mutanten : eine Untersuchung im heterotopen Rattenmodell
… Oberschenkel implantiert. Die Konzentration der Morphogene bzw. von rhBMP-2 betrugen 0,25, 0,5, 1, 2 und 4µg. Zum Vergleich kamen Leerproben der ICBM-Träger ohne Morphogen. Während des Versuchszeitraums von 28 Tagen wurden die Ratten am 5., 11., 17., 23. und 28. vital geröntgt und mittels …
-
Morphogenetic signaling in growing tissues
… are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a graded concentration profile. Upon binding of the morphogens to receptors on the cell surfaces, the morphogenetic signal is transduced …
-
Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery
… Hh ligand transport known as cytoneme-mediated morphogen transport. This method of morphogen transport utilizes fragile, thin cytoplasmic extensions which deliver cargo directly from the source of production to ligand responding cells. Through the use of a modified electron microscopy fixative, …
-
Molecular mechanism of glycogen phosphorylase gene regulation during Dictyostelium development
… gene since the former molecule is a spore-cell morphogen, while the latter is a stalk-cell morphogen. A model of gp2 gene regulation during development is proposed, based on these findings. The two gp? introns and the 45 bp CAA repeat were studied by deletion of these elements. However, there …
-
The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… a pattern ventrally is tightly regulated by Shh morphogen, released by cells of organising centres in the ventral midline of the embryo, namely the floor plate and the notochord. In recent years, a lot of research has been carried out to understand how cells interpret the Shh signal and translate …
-
The Role of Sonic Hedgehog in the Hypothalamus
… Douglas J. Epstein Sonic hedgehog (Shh) is a morphogen secreted during early development that is required for the formation of the ventral neural tube, including the ventral forebrain. The prechordal source of Shh underlying the forebrain is required early to bifurcate the cerebral hemispheres …
-
Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …
-
Quantitative Characterization of Conserved Noncoding Regions by Flow Cytometry
… indicate a regulatory region critical to basic morphogenesis. CNR-green fluorescent protein (GFP) constructs can demonstrate spatial and temporal CNR activity by microscopy visualization. However, characterization of regulatory modules within a CNR requires quantitative, in addition to …
Page 1 of 2