Self-Stimulation and Morphine Abstinence in the Rat.

To test the effects of morphine abstinence on shuttlebox self-stimulation, rats were implanted with either a morphine or placebo pellet. Naloxone or saline was administered 48 hours later and animals were observed briefly for abstinence behaviors. Immediately following the observation period, animals were tested in the shuttlebox. Of the ten animals undergoing naloxone-precipitated abstinence, two were behaviorally sedated and had both high ON times and OFF times. The non-sedated abstinent rats self-stimulated at baseline rates. This suggests that an abstinence-induced behavioral sedation masks the reward value of self-stimulation during abstinence and that reward systems supporting self-stimulation function at predrug levels. Discrepancies between these data and previous findings are discussed.

Level thesis:degree_level

Thesis

Year

1982

Author dc:creator

• Goodwin, Judith A

• Placebo pellet
• Abstinence behaviors
• Shuttlebox
• Self-stimulation
• Behavioral sedation

Repository record dc:identifier

https://digitalcommons.library.uab.edu/etd-collection/7090

OAI identifier oai:identifier

oai:digitalcommons.library.uab.edu:etd-collection-8082