Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Self-stimulation"”.
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Self-Stimulation and Morphine Abstinence in the Rat.
… the effects of morphine abstinence on shuttlebox self-stimulation, rats were implanted with either a morphine or placebo pellet. Naloxone or saline was administered 48 hours later and animals were observed briefly for abstinence behaviors. Immediately following the observation period, animals were …
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Shuttlebox Self-Stimulation Behavior Following Intracerebral Microinjections of Morphine Into the Ventral Tegmental-Substantia.
… which rats will lever-press for electrical brain stimulation as well as decrease the current intensity required for this self-stimulation. In the shuttlebox paradigm, the animal crosses from one side of the case to the other in order to turn the current on and off. Similar doses of morphine will …
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The Amelioration of Self-Stimulation in an Autistic Teenager: A View Toward the Environment
… of behavioral intervention on the frequency of self-stimulation emitted by an autistic teenager was studied. Emphasis was placed not only on the strength or weakness of treatment effects, but the influence various environmental stimuli had on the subject's behavior. The subject was studied in …
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The Effects of Cholinergic Agonists and Antagonists on Self-Stimulation Behavior in The Rat
Made available in DSpace on 2014-12-10T21:07:06Z (GMT). No. of bitstreams: 1 7114890.pdf: 4997567 bytes, checksum: 519c991c5c0525840a60e8f548f01765 (MD5) Previous issue date: 1970
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Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
… evidence implicates dopamine in brain stimulation reward. For example, dopamine antagonists or destruction of dopaminergic neurons reduce the reward effectiveness of medial forebrain bundle stimulation. Assessment of such effects is complicated by across-subject averaging and by motor …
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EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS
… by high abuse liability. Intracranial self-stimulation (ICSS) is a preclinical behavioral procedure that has been used to assess abuse potential of opioids, and drug-induced facilitation of ICSS is interpreted as an abuse-related effect. ICSS can also be used as a behavioral baseline to …
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The lateral hypothalamus and energy balance : facilitation and inhibition of perifornical self-stimulation by long- and short-term metabolic signals
Electrical stimulation of certain brain areas produces a robust effect that directs the animal towards obtaining more stimulation. This phenomenon is believed to result from the activation of neural circuits that direct the animal towards naturally-occurring reinforcers such as food. The lateral …
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Influences of Lesions and Stimulation in the Amygdala and Medial Forebrain Bundle on Electrical Self-Stimulation of the Septum in the Hooded Rat
Made available in DSpace on 2014-12-09T23:33:59Z (GMT). No. of bitstreams: 1 6808129.pdf: 6549312 bytes, checksum: fb7192cbf0048bbab7a28821bee6d164 (MD5) Previous issue date: 1967
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Brain Stimulation Reward is Integrated by A Network of Electrically-Coupled GABA Neurons
… it is well-established that animals will self-stimulate electric current to various diverse brain structures, the neural substrate of brain stimulation reward (BSR) has eluded identification since its discovery more than a half-century ago. We show that GABA neurons in the midbrain, …
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Mapping the substrate for brain stimulation reward : new approaches to an old problem
A major goal for research on brain stimulation reward (BSR) is the identification of the directly-activated ("first-stage") neurons subserving the powerfully rewarding effect produced by electrical stimulation of the medial forebrain bundle (MFB). This objective was addressed by combining …
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Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
… and after 15-min periods of electrical brain-stimulation at sites in the ventral tegmental area (VTA) that supported intracranial self-stimulation (ICSS). In the first experiment, both ICSS and yoked-stimulation of the VTA evoked significant increases in extracellular concentrations of DA, its …
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Investigating the influence of LH-projecting BLA neurons upon motivated behavioral responding and appetitive learning
… that the projection may support intracranial self-stimulation (ICSS). Further experiments with in vivo extracellular electrophysiological recordings from LH-projecting BLA neurons may also shed light on the encoding properties of these neurons during appetitive learning.
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A functional MRI study of the distributed neural circuitry of learning and reward
… shown that the reward magnitude of electrical stimulation to structures within this system increases with increasing current and frequency. In this study, operant conditioning with intracranial self-stimulation of the medial forebrain bundle (MFB) was used to correlate the rewarding quality of …
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Determinants of Abuse-Related Effects of Monoamine Releasers in Rats
… in two preclinical assays in rats: intracranial self-stimulation (ICSS) and drug discrimination. First, this work confirmed and expanded upon previous findings that selectivity for promoting release of dopamine versus serotonin is one determinant of abuse-related effects produced by monoamine …
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Characteristics That Discriminate Between Successful and Unsuccessful Drug Withdrawal Candidates Among Mentally Retarded Persons (Neuroleptic, Psychotropic, Major Tranquilizers)
… staff as causing disturbances, displaying self-stimulation, and/or exhibiting physical aggression. None of the demographic variables, number of months on drug, presence of tardive dyskinesia, or more importantly, the behavioral reasons for initial prescription of drugs were found to be …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… related behaviors such as lateral hypothalamus self-stimulation (LHSS). The lateral hypothalamus (LH) is a brain structure with prominent roles in feeding, arousal and reward. Recent studies have found that melanin concentrating hormone (MCH), orexin A and orexin B are exclusively expressed in …
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Treatment Effectiveness in Preschool Education- A Look at Affective Variables
… age at symptom onset and treatment initiation, self-stimulation levels, echolalia, motor planning and language skills, and biomedical factors. No differences were seen between treatment programs on all outcome measures. The individual characteristics of the children played the more significant …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to assess these preclinical effects of cannabinoids is …
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Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
… behavior) or depress intracranial self-stimulation (ICSS) (pain-depressed behavior), whereas, IP injection(s) of lipopolysaccharide (LPS) served as a chronic/acute inflammatory-related noxious stimulus to stimulate mechanical allodynia (pain-stimulated behavior) or depress ICSS …
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Influence of Pramipexole on Probability Discounting and Ventral Pallidal Function: Assessments in Parkinsonian-Like Rats
<p>People with neuropathologies who are treated with dopamine agonists may be at risk to develop impulse control disorders. The overall goal of this dissertation project was to expand our knowledge on the neuropsychopharmacology of dopamine agonist-induced impulsivity. At the time this dissertation …
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