Quantification of Salicylic Acid in Artificial Saliva using Raman Spectroscopy

This study presents the application of Raman spectroscopy for the quantification of salicylic acid (SA) in artificial saliva, addressing the critical need for non-invasive methods to measure medication adherence. Given the recent guidelines advocating for higher aspirin doses for pregnant women at risk for Pre-Eclampsia (PE), a condition that can lead to severe complications for both mother and child, the importance of accurate medication adherence in clinical trials is underscored. The most accurate methods to measure medication adherence, such as blood draws, are considered invasive, thus underscoring the significance of exploring alternative biological fluids, like saliva. Utilising a HORIBA Jobin-Yvon LabRam HR800 spectrometer, this research conducted a detailed study of varying SA concentrations in artificial saliva to determine detection and quantification limits. The findings showed that Raman spectroscopy, complemented by data processing techniques like Savitzky-Golay smoothing and Extended Multiplicative Signal Correction (EMSC), offers a promising methodology for the precise quantification of SA in saliva. This methodological innovation not only simplifies medication adherence measurements but also potentially enhances patient compliance in clinical settings. The findings of this study have broader applications beyond just pharmacy. They set the stage for more widespread use of Raman spectroscopy in analysing biological fluids, changing the way we monitor medication adherence, without invasive methods.

Author dc:creator

• Alexandra Rut Kjærnested 2000-

Contributors dc:contributor

• Háskóli Íslands

• Lyfjafræði

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/1946/46515

OAI identifier oai:identifier

oai:skemman.is:1946/46515