{"id":{"repo_id":"u-iceland","oai_identifier":"oai:skemman.is:1946/46515"},"canonical_url":"https://search.dev.ndltd.org/etd/u-iceland/oai:skemman.is:1946/46515","repository":{"repo_id":"u-iceland","name":"University of Iceland","base_url":"https://skemman.is/oai/request"},"display":{"title":"Quantification of Salicylic Acid in Artificial Saliva using Raman Spectroscopy","abstract":"This study presents the application of Raman spectroscopy for the quantification of salicylic acid (SA) in artificial saliva, addressing the critical need for non-invasive methods to measure medication adherence. Given the recent guidelines advocating for higher aspirin doses for pregnant women at risk for Pre-Eclampsia (PE), a condition that can lead to severe complications for both mother and child, the importance of accurate medication adherence in clinical trials is underscored. The most accurate methods to measure medication adherence, such as blood draws, are considered invasive, thus underscoring the significance of exploring alternative biological fluids, like saliva. Utilising a HORIBA Jobin-Yvon LabRam HR800 spectrometer, this research conducted a detailed study of varying SA concentrations in artificial saliva to determine detection and quantification limits. The findings showed that Raman spectroscopy, complemented by data processing techniques like Savitzky-Golay smoothing and Extended Multiplicative Signal Correction (EMSC), offers a promising methodology for the precise quantification of SA in saliva. This methodological innovation not only simplifies medication adherence measurements but also potentially enhances patient compliance in clinical settings. The findings of this study have broader applications beyond just pharmacy. They set the stage for more widespread use of Raman spectroscopy in analysing biological fluids, changing the way we monitor medication adherence, without invasive methods.","abstract_html":"This study presents the application of Raman spectroscopy for the quantification of salicylic acid (SA) in artificial saliva, addressing the critical need for non-invasive methods to measure medication adherence. Given the recent guidelines advocating for higher aspirin doses for pregnant women at risk for Pre-Eclampsia (PE), a condition that can lead to severe complications for both mother and child, the importance of accurate medication adherence in clinical trials is underscored. The most accurate methods to measure medication adherence, such as blood draws, are considered invasive, thus underscoring the significance of exploring alternative biological fluids, like saliva. Utilising a HORIBA Jobin-Yvon LabRam HR800 spectrometer, this research conducted a detailed study of varying SA concentrations in artificial saliva to determine detection and quantification limits. The findings showed that Raman spectroscopy, complemented by data processing techniques like Savitzky-Golay smoothing and Extended Multiplicative Signal Correction (EMSC), offers a promising methodology for the precise quantification of SA in saliva. This methodological innovation not only simplifies medication adherence measurements but also potentially enhances patient compliance in clinical settings. The findings of this study have broader applications beyond just pharmacy. They set the stage for more widespread use of Raman spectroscopy in analysing biological fluids, changing the way we monitor medication adherence, without invasive methods.","abstract_has_math":false,"creators":["Alexandra Rut Kjærnested 2000-"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Háskóli Íslands"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-04-16T14:40:05Z","date_published":"2024-04-16T14:40:05Z","updated_at":"2026-07-27T21:40:16Z","subjects":["Lyfjafræði"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1946/46515","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Háskóli Íslands"]},{"key":"dc:creator","label":"Author","values":["Alexandra Rut Kjærnested 2000-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-04-16T14:40:05Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-04-16T14:40:05Z"]},{"key":"dc:date.issued","label":"Date","values":["2024-04-16T14:40:05Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Lyfjafræði"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1946/46515"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This study presents the application of Raman spectroscopy for the quantification of salicylic acid (SA) in artificial saliva, addressing the critical need for non-invasive methods to measure medication adherence. Given the recent guidelines advocating for higher aspirin doses for pregnant women at risk for Pre-Eclampsia (PE), a condition that can lead to severe complications for both mother and child, the importance of accurate medication adherence in clinical trials is underscored. The most accurate methods to measure medication adherence, such as blood draws, are considered invasive, thus underscoring the significance of exploring alternative biological fluids, like saliva. Utilising a HORIBA Jobin-Yvon LabRam HR800 spectrometer, this research conducted a detailed study of varying SA concentrations in artificial saliva to determine detection and quantification limits. The findings showed that Raman spectroscopy, complemented by data processing techniques like Savitzky-Golay smoothing and Extended Multiplicative Signal Correction (EMSC), offers a promising methodology for the precise quantification of SA in saliva. This methodological innovation not only simplifies medication adherence measurements but also potentially enhances patient compliance in clinical settings. The findings of this study have broader applications beyond just pharmacy. They set the stage for more widespread use of Raman spectroscopy in analysing biological fluids, changing the way we monitor medication adherence, without invasive methods.","Þessi rannsókn lýsir því hvernig hægt er að beita Raman litrófsgreiningu til að magngreina salisýlsýru í munnvatni. Aðferðin sem þróuð var í rannsókninni leggur áherslu á mikilvægi þess að þróa aðferðir sem krefjast minna inngrips til að meta meðferðarheldni í klínískum rannsóknum. Nýlegar breytingar á ráðlögðum dagskammti af aspiríni undirstrika þörfina fyrir klínískum rannsóknum sem meta öryggi og virkni aukins skammts. Meðferðarheldni er lykilþáttur í árangri klínískra rannsókna, og því er nauðsynlegt að beita nákvæmum aðferðum til að mæla hana. Í rannsókninni var notaður HORIBA Jobin-Yvon LabRam HR800 litrófsmælir til að framkvæma ítarlega greiningu á mismunandi styrk salisýlsýru, með það að markmiði að ákvarða greiningar- og magngreiningarmörk í munnvatni. Niðurstöður benda til þess að Raman litrófsgreining, í samspili við forvinnsluaðferðir á borð við Savitsky-Golay sléttun og EMSC, sé árangursrík aðferð til magngreiningar á salisýlsýru í munnvatni. Aðferðin sem lýst er í þessari rannsókn auðveldar ekki aðeins mælingar á meðferðarheldni, heldur gæti einnig hvatt til betri meðferðarheldni meðal þátttakenda í klínískum rannsóknum. Þessar niðurstöður opna fyrir notkun Raman litrófsgreiningar í víðara samhengi en eingöngu í lyfjafræði, þar sem þær leggja grunn að notkun tækninnar í greiningu lyfja í líffræðilegum vökvum og breyta þannig hvernig meðferðarheldni er mæld með aðferðum sem ekki þarfnast inngrips."]},{"key":"dc:title","label":"Title","values":["Quantification of Salicylic Acid in Artificial Saliva using Raman Spectroscopy"]}]}],"canonical_facts":{"dc:contributor":["Háskóli Íslands"],"dc:creator":["Alexandra Rut Kjærnested 2000-"],"dc:date.accessioned":["2024-04-16T14:40:05Z"],"dc:date.available":["2024-04-16T14:40:05Z"],"dc:date.issued":["2024-04-16T14:40:05Z"],"dc:description.abstract":["This study presents the application of Raman spectroscopy for the quantification of salicylic acid (SA) in artificial saliva, addressing the critical need for non-invasive methods to measure medication adherence. Given the recent guidelines advocating for higher aspirin doses for pregnant women at risk for Pre-Eclampsia (PE), a condition that can lead to severe complications for both mother and child, the importance of accurate medication adherence in clinical trials is underscored. The most accurate methods to measure medication adherence, such as blood draws, are considered invasive, thus underscoring the significance of exploring alternative biological fluids, like saliva. Utilising a HORIBA Jobin-Yvon LabRam HR800 spectrometer, this research conducted a detailed study of varying SA concentrations in artificial saliva to determine detection and quantification limits. The findings showed that Raman spectroscopy, complemented by data processing techniques like Savitzky-Golay smoothing and Extended Multiplicative Signal Correction (EMSC), offers a promising methodology for the precise quantification of SA in saliva. This methodological innovation not only simplifies medication adherence measurements but also potentially enhances patient compliance in clinical settings. The findings of this study have broader applications beyond just pharmacy. They set the stage for more widespread use of Raman spectroscopy in analysing biological fluids, changing the way we monitor medication adherence, without invasive methods.","Þessi rannsókn lýsir því hvernig hægt er að beita Raman litrófsgreiningu til að magngreina salisýlsýru í munnvatni. Aðferðin sem þróuð var í rannsókninni leggur áherslu á mikilvægi þess að þróa aðferðir sem krefjast minna inngrips til að meta meðferðarheldni í klínískum rannsóknum. Nýlegar breytingar á ráðlögðum dagskammti af aspiríni undirstrika þörfina fyrir klínískum rannsóknum sem meta öryggi og virkni aukins skammts. Meðferðarheldni er lykilþáttur í árangri klínískra rannsókna, og því er nauðsynlegt að beita nákvæmum aðferðum til að mæla hana. Í rannsókninni var notaður HORIBA Jobin-Yvon LabRam HR800 litrófsmælir til að framkvæma ítarlega greiningu á mismunandi styrk salisýlsýru, með það að markmiði að ákvarða greiningar- og magngreiningarmörk í munnvatni. Niðurstöður benda til þess að Raman litrófsgreining, í samspili við forvinnsluaðferðir á borð við Savitsky-Golay sléttun og EMSC, sé árangursrík aðferð til magngreiningar á salisýlsýru í munnvatni. Aðferðin sem lýst er í þessari rannsókn auðveldar ekki aðeins mælingar á meðferðarheldni, heldur gæti einnig hvatt til betri meðferðarheldni meðal þátttakenda í klínískum rannsóknum. Þessar niðurstöður opna fyrir notkun Raman litrófsgreiningar í víðara samhengi en eingöngu í lyfjafræði, þar sem þær leggja grunn að notkun tækninnar í greiningu lyfja í líffræðilegum vökvum og breyta þannig hvernig meðferðarheldni er mæld með aðferðum sem ekki þarfnast inngrips."],"dc:identifier.uri":["http://hdl.handle.net/1946/46515"],"dc:language.iso":["en"],"dc:subject":["Lyfjafræði"],"dc:title":["Quantification of Salicylic Acid in Artificial Saliva using Raman Spectroscopy"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T21:40:16Z"}