Chlorhexidine Interaction with Microcrystalline Cellulose

Chlorhexidine, widely used as a disinfectant and antiseptic in medical and dental applications, reacts with sodium hypochlorite, a common cleanser and bleach, forming potentially toxic byproducts. This reaction is particularly concerning in both medical settings and everyday laundering, where chlorhexidine-treated fabrics washed with bleach develop permanent stains due to chemical interactions with cellulose fibers. Previous research has identified compounds such as Parachloroaniline (PCA), which contribute to both toxicity and fiber degradation. This study aims to further analyze the breakdown products of chlorhexidine and sodium hypochlorite using Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). By examining microcrystalline cellulose as a model, we will investigate the mechanisms of staining and toxicity. Identifying these reaction products will improve our understanding of chlorhexidine’s interactions with bleach and textiles, guiding safer use in healthcare and environmental settings.

Name thesis:degree_name

Master of Science

Discipline thesis:degree_discipline

Chemistry & Biochemistry

Grantor

Texas Woman's University

Year dc:date.issued

2025

Author dc:creator

• Joshi, Utsav

Advisor dc:contributor.advisor

• Beatty, John

Committee members dc:contributor.committeemember

• Salazar, Gustavo
• Petros, Robby

• Chemistry, Organic
• Chlorhexidine
• Cellulose
• Stain
• Gas chromatography-mass spectrometry (GC-MS)
• High-performance liquid chromatography (HPLC)

Language dc:language.iso

English

Handle dc:identifier.uri

https://hdl.handle.net/11274/17405

OAI identifier oai:identifier

oai:twu-ir.tdl.org:11274/17405