{"id":{"repo_id":"twu","oai_identifier":"oai:twu-ir.tdl.org:11274/17405"},"canonical_url":"https://search.dev.ndltd.org/etd/twu/oai:twu-ir.tdl.org:11274/17405","repository":{"repo_id":"twu","name":"Texas Woman's University","base_url":"https://twu-ir.tdl.org/server/oai/request"},"display":{"title":"Chlorhexidine Interaction with Microcrystalline Cellulose","abstract":"Chlorhexidine, widely used as a disinfectant and antiseptic in medical and dental applications, reacts with sodium hypochlorite, a common cleanser and bleach, forming potentially toxic byproducts. This reaction is particularly concerning in both medical settings and everyday laundering, where chlorhexidine-treated fabrics washed with bleach develop permanent stains due to chemical interactions with cellulose fibers. Previous research has identified compounds such as Parachloroaniline (PCA), which contribute to both toxicity and fiber degradation. This study aims to further analyze the breakdown products of chlorhexidine and sodium hypochlorite using Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). By examining microcrystalline cellulose as a model, we will investigate the mechanisms of staining and toxicity. Identifying these reaction products will improve our understanding of chlorhexidine’s interactions with bleach and textiles, guiding safer use in healthcare and environmental settings.","abstract_html":"Chlorhexidine, widely used as a disinfectant and antiseptic in medical and dental applications, reacts with sodium hypochlorite, a common cleanser and bleach, forming potentially toxic byproducts. This reaction is particularly concerning in both medical settings and everyday laundering, where chlorhexidine-treated fabrics washed with bleach develop permanent stains due to chemical interactions with cellulose fibers. Previous research has identified compounds such as Parachloroaniline (PCA), which contribute to both toxicity and fiber degradation. This study aims to further analyze the breakdown products of chlorhexidine and sodium hypochlorite using Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). By examining microcrystalline cellulose as a model, we will investigate the mechanisms of staining and toxicity. Identifying these reaction products will improve our understanding of chlorhexidine’s interactions with bleach and textiles, guiding safer use in healthcare and environmental settings.","abstract_has_math":false,"creators":["Joshi, Utsav"],"institution":"Texas Woman's University","degree_name":"Master of Science","degree_level":null,"degree_discipline":"Chemistry & Biochemistry","degree_department":null,"school":null,"contributors":[],"advisors":["Beatty, John"],"committee_chairs":[],"committee_members":["Salazar, Gustavo","Petros, Robby"],"year":2025,"date_issued":"2025-12","date_published":"2025-12","updated_at":"2026-07-24T05:05:11Z","subjects":["Chemistry, Organic","Chlorhexidine","Cellulose","Stain","Gas chromatography-mass spectrometry (GC-MS)","High-performance liquid chromatography (HPLC)"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/11274/17405","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Beatty, John"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Salazar, Gustavo","Petros, Robby"]},{"key":"dc:creator","label":"Author","values":["Joshi, Utsav"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2026-02-18T02:23:26Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-12"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry & Biochemistry"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Texas Woman's University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic","Chlorhexidine","Cellulose","Stain","Gas chromatography-mass spectrometry (GC-MS)","High-performance liquid chromatography (HPLC)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/11274/17405"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Accessibility remediation is in progress for this item"]},{"key":"dc:description.abstract","label":"Abstract","values":["Chlorhexidine, widely used as a disinfectant and antiseptic in medical and dental applications, reacts with sodium hypochlorite, a common cleanser and bleach, forming potentially toxic byproducts. This reaction is particularly concerning in both medical settings and everyday laundering, where chlorhexidine-treated fabrics washed with bleach develop permanent stains due to chemical interactions with cellulose fibers. Previous research has identified compounds such as Parachloroaniline (PCA), which contribute to both toxicity and fiber degradation. This study aims to further analyze the breakdown products of chlorhexidine and sodium hypochlorite using Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). By examining microcrystalline cellulose as a model, we will investigate the mechanisms of staining and toxicity. Identifying these reaction products will improve our understanding of chlorhexidine’s interactions with bleach and textiles, guiding safer use in healthcare and environmental settings."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Chlorhexidine Interaction with Microcrystalline Cellulose"]}]}],"canonical_facts":{"dc:contributor.advisor":["Beatty, John"],"dc:contributor.committeemember":["Salazar, Gustavo","Petros, Robby"],"dc:creator":["Joshi, Utsav"],"dc:date.accessioned":["2026-02-18T02:23:26Z"],"dc:date.issued":["2025-12"],"dc:description":["Accessibility remediation is in progress for this item"],"dc:description.abstract":["Chlorhexidine, widely used as a disinfectant and antiseptic in medical and dental applications, reacts with sodium hypochlorite, a common cleanser and bleach, forming potentially toxic byproducts. This reaction is particularly concerning in both medical settings and everyday laundering, where chlorhexidine-treated fabrics washed with bleach develop permanent stains due to chemical interactions with cellulose fibers. Previous research has identified compounds such as Parachloroaniline (PCA), which contribute to both toxicity and fiber degradation. This study aims to further analyze the breakdown products of chlorhexidine and sodium hypochlorite using Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). By examining microcrystalline cellulose as a model, we will investigate the mechanisms of staining and toxicity. Identifying these reaction products will improve our understanding of chlorhexidine’s interactions with bleach and textiles, guiding safer use in healthcare and environmental settings."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/11274/17405"],"dc:language.iso":["English"],"dc:subject":["Chemistry, Organic","Chlorhexidine","Cellulose","Stain","Gas chromatography-mass spectrometry (GC-MS)","High-performance liquid chromatography (HPLC)"],"dc:title":["Chlorhexidine Interaction with Microcrystalline Cellulose"],"dc:type":["Thesis"],"thesis:degree_discipline":["Chemistry & Biochemistry"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Texas Woman's University"]},"updated_at":"2026-07-24T05:05:11Z"}