The effects of niacin and a single bout of exercise on blood lipid and lipoprotein profiles in postmenopausal women

It has been well documented that independently both exercise and niacin positively alter blood lipids and lipoproteins; however, these interventions have not been studies in postmenopausal women. The purpose of this study was to examine the independent and combined effects of niacin and a single bout of exercise on the blood lipid and lipoprotein profiles in postmenopausal women. Eighteen sedentary, postmenopausal women (40-80 years old), were recruited (mean ± SD; age = 57 ± 6 yrs; height = 161.3 ± 6.7 cm; weight = 75.8 ± 13.9 kg; % body fat = 46.2 ± 6.6%). The without-niacin (WON) condition was first assigned followed by the with-niacin (WN) condition. The WN condition consisted of ingesting 1,000 mg/day of extended-release niacin for 4 weeks. Rest (R) and exercise (E) trials were randomly assigned within each WON or WN condition. During the E trial treadmill exercise was performed at 60% HRR until 400 kcal were expended. Fasting blood samples were collected immediately before (0 hr) and at 24 and 48 hr post exercise (or rest). All data were reported as mean ± SD. The changes in TC, TG, LDL-C, HDL-C, HDL2-C, HDL3-C, and TC to HDL-C ratio were analyzed using a 2 (WON and WN) x 2 (Rest and Exercise) x 3 (0, 24, and 48 hr) ANOVA with repeated measures. The Bonferroni post-hoc test was applied and the statistical significance was set at p < .05. The concentrations of TC, LDL-C, and TG were not altered in responses to exercise or niacin. However, the niacin treatment without the exercise intervention significantly (p < .05) increased HDL-C (5.4 mg/dl or 12.4%) and HDL2-C (3.6 mg/dl or 33.3%) from baseline (43.5 ± 1.7 and 10.8 ± 1.2 mg/dl, respectively). The current study suggests that the niacin supplement (1,00 mg/day) for 4 weeks increased HDL-C, predominantly HDL2-C.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Kinesiology

Grantor

Texas Woman's University

Year dc:date.issued

2008

Author dc:creator

• Koh, Yunsuk

Chair dc:contributor.committeechair

• Ben-Ezra, Vic

Committee members dc:contributor.committeemember

• Biggerstaff, Kyle
• Nichols, David
• DiMarco, Nancy

• Niacin
• Postmenopausal
• Blood lipid

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/11274/15574

OAI identifier oai:identifier

oai:twu-ir.tdl.org:11274/15574