Estradiol and chlordecone interactions with the estrogen receptor

The in vivo and in vitro effects of the chlorinated pesticide, chlordecone, on the estradiol receptor of adult ovariectomized CDF-344 rats were examined. Chlordecone's competition for $\sp3$H-estradiol binding in vitro was similar whether receptors were derived from neural or uterine tissue. In vivo, chlordecone led to nuclear retention of estradiol receptors in both tissues, but in comparison to estradiol, the latency for such retention was slower following chlordecone. Nevertheless, chlordecone and estradiol treated animals eventually achieved the same degree of nuclear retention in uterine tissue. In brain, estradiol-like levels of nuclear retention were never found in chlordecone treated females. Estradiol receptor replenishment following chlordecone or estradiol was similar in uterine tissue but not in brain. Chlordecone's lesser ability to mimic estradiol's receptor dynamics in the brain may contribute to the apparent tissue differences in chlordecone's estrogenicity.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Molecular biology

Grantor

Texas Woman's University

Year dc:date.issued

1988

Author dc:creator

• Williams, Judy

Chair dc:contributor.committeechair

• Uphouse, Lynda

Committee member dc:contributor.committeemember

• Hines, John

• Estrogen receptor
• Chlordecone

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/11274/14002

OAI identifier oai:identifier

oai:twu-ir.tdl.org:11274/14002