Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 491 for “"Estradiol"”.
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Fate of 17α-Estradiol, 17β-Estradiol, and Estrone in Agricultural Soils and Sediments
… tons of the natural manure-borne estrogens, 17α-estradiol (17α-E2), 17β-estradiol (17β-E2), and estrone (E1). While these estrogens are critical to endocrine systems, the low concentrations observed in the environment can disrupt endocrine function in non-target organisms, e.g., altering …
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Selecting DNA aptamers for 17β-estradiol
17β-estradiol (E2) is a potent estrogen that has been widely documented in water resources. It falls under the category of endocrine disrupting compounds (EDCs), and hence has been included in the EPA’s Unregulated Contaminant Monitoring Rule (UCM3) that will require the monitoring of this …
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
… estrogens such as synthetic 17α-ethinyl estradiol (EE) occurs via multiple sources (i.e. hormonal contraceptives, environmental contamination, hormone replacement therapy). The natural estrogen, 17β-estradiol (E2), is a well-studied immunomodulatory hormone at both environmental and …
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Estradiol and chlordecone interactions with the estrogen receptor
… the chlorinated pesticide, chlordecone, on the estradiol receptor of adult ovariectomized CDF-344 rats were examined. Chlordecone's competition for $\sp3$H-estradiol binding in vitro was similar whether receptors were derived from neural or uterine tissue. In vivo, chlordecone led to nuclear …
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Design and synthesis of rotational analogues of estradiol
… conducted in synthesising bridged analogues of estradiol in which the ring D hydroxy group is displaced from the 17-position. The aim was to explore the possible rotational equivalence between such analogues and estr~diol. The synthetic routes investigated were based upon cycloaddition to …
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Circadian rhythm of cortisol and estradiol in healthy women
… <p>CIRCADIAN RHYTHM OF CORTISOL AND ESTRADIOL IN HEALTHY WOMEN</p> <p>by</p> <p>KARYN G. BUTLER</p> <p>AUGUST 2011</p> <p>Advisor: Dr. Jean E. Davis</p> <p>Major: Nursing</p> <p>Degree: Doctor of Philosophy</p> <p>Daily variation in human processes and behaviors has been identified …
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The role of estradiol in astrocyte and neuron communication
… whether astrocytes responded to the estrogen 17β-estradiol (E2). Lastly, I used electrophysiology to test whether E2-evoked astrocyte activity could regulate neuronal activity and excitatory synaptic transmission. I describe results in Chapter 3 showing that females and males express ERα and ERβ …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… points in a woman's life, changes in circulating estradiol are associated with disturbances in mood and cognitive function. To determine the biological basis of these behavioral changes, researchers have concentrated on the hippocampal formation, a medial temporal lobe structure involved in the …
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Estradiol and Daily Affective Experiences in Trauma-Exposed Women
… by fluctuations in levels of sex hormones (e.g., estradiol), which could influence physiological responses to trauma reminders. Additionally, previous work has linked the sex hormone estradiol with affect, suggesting that menstrual cycle might influence trauma-related symptoms or daily affect more …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… were found to decrease following treatment with estradiol. Additionally, estradiol was found to decrease the doubling time of these cells, while sulfasalazine increased the doubling time. Interestingly, it was found that estradiol decreased the doubling time of MCF-7 cells when compared to cells …
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Synthesis and structure-activity studies of skeletally modified estradiol analogues
… introduction of a 14, 17-ethano bridge into the estradiol skeleton. 3-Methoxyestra-1,3,5(10)-trien-17-one was converted conventionally into the 13α-isomer, which underwent sequential silyl enol ether formation and dehydrosilylation into 3-methoxy-13α-estra-1,3,5(10), 15-tetraen-17-one, which …
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Estradiol regulation of the neurohypophysial hormones in the goldfish, Carassius auratus.
… the regulation of NH gene expression by estradiol was examined in the goldfish, Carassius auratus. (Abstract shortened by UMI.)
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How HPA stress response relates to anxiety: Sex differences and estradiol
1 PDF file (viii, 58 pages)
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Regulation of Micrornas by 17β-Estradiol in the Aging Female Brain
… Therapy (HT) is used to increase the 17β-estradiol (E2) levels in women who are going through the menopausal transition to alleviate the negative symptoms associated with menopause and decrease the risk of chronic diseases. Clinical and basic science research had previously shown that HT …
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Estradiol Has Distinct Effects on the Hippocampal and Striatal Memory Systems
… these studies highlight the distinct actions of estradiol in the hippocampus to enhance place learning and in the striatum to impair response learning. By altering the responsiveness of hippocampal and striatal cells to experience, estradiol biases the type of information obtained, resulting in …
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Modulation of humoral immunity in the rat by 17beta-estradiol and prolactin
… Many studies have shown that prolactin (PRL) and estradiol (E$\sb2$) augment immunity. Given that E$\sb2$ is a potent physiologic stimulus for the release of PRL from the pituitary, it is plausible that PRL mediates the influence of E$\sb2$ upon the immune system. To test this hypothesis, we …
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Estradiol-17beta-Oxytocin Induced Cervical Dilation in Sheep: Application to Transcervical Embryo
… were initiated to determine whether exogenous estradiol-17beta (E2) and oxytocin (OT) can be used to dilate the cervix and improve transcervical embryo transfer (ET) procedures for sheep. However, there was concern that the E2-OT treatment may alter luteal function and that embryo quality would …
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
… and congeners, and in combination with estradiol (E2), while also automating these assays to facilitate future screening of a potentially large number of XEs. METHODOLOGY: Environmentally relevant concentrations of XEs (10-15-10-7M) were assessed individually and as mixtures by …
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