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Università degli studi di Trento
Unbalancing Polycomb group proteins activities during liver homeostasis and tumour formation
Abstract
dc:descriptionIncreasing evidence demonstrated that mutations altering the activity of chromatin-modifying complexes significantly contribute to liver tumour formation and progression. Inactivating mutations of members of the polycomb complexes have been found in a subset of aggressive HCCs, mainly affecting women, and in more than 20% of CCA. To clarify the role of these chromatin-associated complexes in liver homeostasis, we used a comprehensive approach taking advantage of advanced genomics approaches, histological and histochemical techniques and novel in vivo models. Our data suggest that unbalancing Polycomb activities compromises liver homeostasis, favouring tumour formation.
Degree
thesis:*- Grantor dc:publisher
- Università degli studi di Trento
- Year dc:date
- 2025
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Ferracci, Elisa
- Contributors dc:contributor
-
- Chiacchiera, Fulvio
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/closedAccess
- license:Tutti i diritti riservati (All rights reserved)
- license uri:iris.PRI01
- Language dc:language
- eng
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:iris.unitn.it:11572/443230