Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Polycomb"”.
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The function of E2F6 in the Polycomb complex
… transcription through the recruitment of the Polycomb Group (PcG) complex. This complex is responsible for the maintenance of Hox gene expression patterns during development and thus ensures the correct anterior-posterior segmentation of the embryo. Genetic ablation of PcG proteins leads to …
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CRAMP1 drives linker histone expression to enable Polycomb repression
… for linker histones in the function of Polycomb Repressive complex 2 (PRC2) in human cancer cell lines. Through a CRISPR/Cas9 genetic screen in a fluorescent reporter cell line responsive to PRC2 perturbation, I identified an essential requirement for the poorly characterised gene CRAMP1 …
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Molecular regulation of Polycomb complexes in mouse embryonic stem cells
Contains fulltext : 203027.pdf (Publisher’s version ) (Open Access)
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
Polycomb group proteins are key transcriptional repressive complexes involved in cell fate decisions during development and cell identity maintenance during homeostasis (1). Polycomb group proteins primarily assemble into two different complexes: Polycomb repressive complex 2 (PRC2) with the …
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Unbalancing Polycomb group proteins activities during liver homeostasis and tumour formation
… Inactivating mutations of members of the polycomb complexes have been found in a subset of aggressive HCCs, mainly affecting women, and in more than 20% of CCA. To clarify the role of these chromatin-associated complexes in liver homeostasis, we used a comprehensive approach taking …
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Roles of Polycomb Repressive Complex 2 in differentiation and lineage commitment
Contains fulltext : 310092.pdf (Publisher’s version ) (Open Access)
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Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance
Polycomb group (PcG) proteins are epigenetic gene silencers that have been implicated in stem cell maintenance and cancer development. Genetic and biochemical studies indicate that Polycomb group proteins exist in at least two protein complexes, Polycomb repressive complex 2 (PRC2) and Polycomb …
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Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
… local chromatin compaction is regulated is by polycomb repressive complexes. They build a machinery that deposit the histone modifications H3K27me3 and H2AK119Ub at target genes and were shown to impose chromatin compaction. To test the possibility of FGF/ERK regulated polycomb mediated …
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Discovery and Characterization of the Polycomb Repressive Complex 1 of C. Elegans
… of MIG-32 a RING protein similar to some Polycomb proteins that were identified in a yeast two hybrid screen with UNC-3 as bait. The Polycomb repression complex 2 (PRC2) methylates histone H3 lysine 27 at target genes to modify gene expression, and this mark is recognized by PRC1, which …
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The role of Polycomb-mediated epigenetic regulation in embryonic stem cell differentiation
… gene expression networks for this process? Polycomb group (PcG) proteins are epigenetic regulators necessary for proper differentiation of cells and for mammalian development. Notably, faulty regulation of PRC2 has been associated with a broad range of cancers, suggesting that it has a …
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Regulation of cellular memory by non-coding transcription through Polycomb group response elements
… the antagonizing activities of repressive PcG (Polycomb group) and activating TrxG (Trithorax group) proteins. The recruitment of both PcG as well as TrxG proteins to their target loci depends on the presence of identical cis-regulatory elements termed Polycomb group response elements, or PREs. …
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Entwicklung eines DNA Microarrays zur genomweiten Analyse Polycomb-vermittelter Genregulation in Drosophila melanogaster
… bezeichneten Prozess spielen, sind die Polycomb-Gruppe und die trithorax-Gruppe. Während die trithorax- Gruppe die Aufgabe erfüllt, das Expressionsmuster von aktiven Genen während der Entwicklung aufrecht zu erhalten, kommt der Polycomb-Gruppe die Aufgabe zu, den reprimierten Zustand von …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
Polycomb repressive complex 2 (PRC2) catalyses the methylation of ‘Lys-27’ of histone H3, leading to transcriptional repression of target genes through its catalytic subunit Enhancer of zeste homolog 1/2 (EZH1/2). PRC2 functions as a critical regulator of stem cells in mouse embryonic and adult …
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Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
The B lymphoma Mo-MLV insertion region 1 homolog (Bmil) protein is implicated as an oncogene in a variety of human cancers. During normal development, Bmil acts as part of a transcriptional repressive complex that regulates processes such as stem cell self-renewal, cell-fate commitment, and …
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DEFINING THE ROLE OF THE PCGF3-CONTAINING POLYCOMB REPRESSIVE COMPLEX 1 IN SYNOVIAL SARCOMA
… disrupting BAF complexes and redirecting them to Polycomb repressive domains, thus activating them. This mislocalization depends on the higher affinity of the fusion oncoprotein for H2AK119ub, the histone modification deposited by Polycomb Repressive Complex 1 (PRC1). However, the precise …
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The Polycomb Complex 2 contributes to developmental delay when histone methylation is inappropriately inherited
… delay. Work from the Strome Lab showed that the Polycomb Repressive Complex II (PRC2), which includes the H3K27 methyltransferase, MES-2, antagonizes MES-4 activity to maintain proper gene expression during early embryogenesis. This data hints that in the absence of SPR-5 and MET-2 maternal …
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Core Components Of The Nuclear Pore Bind Unique States Of Chromatin And Mediate Polycomb Repression
… and active chromatin, while Nup93 overlaps with Polycomb silenced chromatin regions. Importantly, we found that Nup93 interacts with members of both PRC1 and PRC2 complexes and is enriched for the most tightly regulated Polycomb binding domains. Importantly, we found that Nup93’s association with …
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Investigating the role of the Polycomb Repressive Complex 2 in human in vitro pancreatic differentiation
… the in vitro cells. I show that manipulation of Polycomb protein-mediated H3K27me3 levels in differentiation at specific time-points has a variable effect on end-cell population, with an apparently negative effect early in differentiation, but with potentially a more positive effect later in the …
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Fasting alters histone methylation in paraventricular nucleus of chick through regulating of polycomb repressive complex 2
… respectively. EZh2 (enhancer of zeste 2) in the polycomb repressive complex 2 (PRC2) is the only methyltransferase that has been linked to catalyze this methylation reaction. In addition, SUZ (suppressor of zeste) and EED (embryonic ectoderm development) are two other key proteins in PRC2 …
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