Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering

Due to the complexities of tissue repair or regeneration processes, effective clinical strategies have been impaired by both poor delivery of therapeutic agents to the site of injury and a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the context of these regenerative medicine challenges. An affinity-based system was developed whereby transient interactions between complementary binding partners were used to slow the diffusional release of a therapeutic from a polymeric delivery matrix. The Src homology 3 (SH3) domain, which binds a library of SH3-binding peptides, with varying affinity (10

Department dc:contributor.department

Chemistry

Year dc:date.issued

2014

Author dc:creator

• Vulic, Katarina

Advisor dc:contributor.advisor

• Molly, S. Shoichet

• affinity release
• bioconjugation
• controlled release
• drug delivery
• mathematical modelling
• protein release

Handle dc:identifier.uri

http://hdl.handle.net/1807/68307

OAI identifier oai:identifier

oai:utoronto.scholaris.ca:1807/68307