Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 191 for “"Injectable"”.
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Injectable supramolecular hydrogels for insulin delivery
… blood glucose fluctuations. There is a need for injectable carrier systems which can show therapeutically relevant insulin delivery to the body. Here, we develop injectable shear-thinning hydrogel systems as a depot for modulating the release of insulin. We have used supramolecular hydrogels …
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Injectable Systems for Long-Lasting Insulin Therapy
… insulin release for more than one day, different injectable delivery systems including microspheres, in situ forming depots, nanoparticles and composite systems have been developed for sustained release of insulin for days to weeks in in vitro and preclinical studies. Several of these delivery …
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Signal Conditioning Circuits for Injectable Pressure Sensors
… by minimally invasive methods such as an injectable pressure sensor. However, creating injectable sensors requires highly integrated pressure sensor signal conditioning circuits to be developed as current methods are larger than those that can be included in an injectable device. …
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Injectable polymer for in vivo oxygen sensing
This thesis documents the synthesis and characterization of an elastomeric polymer that is oxygen sensitive and can be interrogated using Magnetic Resonance Imaging (MRI) or Magnetic Resonance (MR) technology to report the oxygen tension in vivo at the site of implant. The polymer was tested for …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… seeks to develop smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… seeks to develop smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low …
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Injectable hyaluronic acid scaffolds for cartilage tissue engineering
… the motivation of this thesis is to develop an injectable scaffold that can be administered in a minimally invasive manner, and that allows for scaffold formation in situ, naturally shaping the construct into the shape of the defect, and thus promoting integration and stability To this end, we …
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INJECTABLE HYBRID HYDROGELS FOR LOCAL CHEMOTHERAPY OR TUMOR-SPECIFIC RESECTION
The aim of my thesis is to develop cutting-edge and innovative delivery system able to encapsulate active molecules against cancer. The purpose is to have a material that can target directly the tumoral environment, avoiding the toxicity to surrounded organs and enhancing the local pharmacological …
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Injectable in situ Gelling Metronidazole System for Treating Jawbone Infections
An untreated dental cavity or an accumulation of bacteria in the side of the teeth or around an implant can cause jawbone infection. This is treated by incision and drainage, root canal treatment or extraction in combination with a prolonged course of antibiotic therapy. Metronidazole is effective …
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Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
… forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the scaffold properties; and a deeper understanding of the relation of select properties to cellular behavior, to provide a rational basis for future in vivo …
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
Due to the complexities of tissue repair or regeneration processes, effective clinical strategies have been impaired by both poor delivery of therapeutic agents to the site of injury and a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… term goal is to develop a versatile and robust injectable carrier based on Mesoporous Silica Nanoparticles (MSN) for drug/drug combination therapies. The objective of my dissertation was to optimize surface functionality, particle shape and methods of colloidal stabilization of mesoporous silica …
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Rheological Studies of Injectable Thermoresponsive Biodegradable Hydrogels and Porcine Ocular Tissues
… which include (i) semi-synthetic polymer-based injectable hydrogels [P(NIPAAm-co-DEX-Lactate HEMA) and P(NIPAAm-co-HA-AEMA)], and (ii) biological tissues (porcine ocular tissues). </p> <p>A series of thermoresponsive and biodegradable in situ hydrogel based on N-isopropyacrylamide (NIPAAm) …
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Peripheral Nervous System Modulation with Wireless Cellular Sized Freestanding Injectable Devices
… substrate-free nanoelectronic devices, termed injectable electronics, can be activated, and controlled using near-infrared (NIR) light, enabling minimally invasive, targeted neuromodulation deep within the peripheral nervous system (PNS). By overcoming the limitations of current implantable …
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Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… address this inadequacy, we designed a versatile injectable hydrogel platform and investigated its utility for local delivery of biomacromolecules to SCI contusion lesions. To develop this hydrogel platform we synthesized a library of different tri-thiol-functionalized ethoxylated polyol esters …
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An Injectable Thermosensitive Hydrogel Potentially Used for Wound Dressing with Self-adhesive Properties
… and sensitivity to physiological environments. Injectable hydrogels can be facilely delivered in vivo without massive impairment to the body, as no surgical incision is needed for hydrogel embedment. This is highly consistent with the need of minimal invasion on human body. Multiple stimuli …
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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel
… subcutaneous injection. <br />A biodegradable injectable drug delivery gel was prepared by dissolving a <br />biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible <br />plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin was <br />then …
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Development of thermally-crosslinked hydrogels as injectable cell carriers for orthopaedic tissue engineering
… (OPF) were developed and characterized as injectable cell carriers for orthopaedic tissue engineering. Through alteration of the poly(ethylene glycol) molecular weight used in the synthesis of the OPF macromer, swelling and mechanical properties of the resulting crosslinked hydrogels could …
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