Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier

The blood-brain barrier (BBB) presents a major obstacle for drugs targeting the brain. Drugs that are small or lipophilic enough can penetrate the physical barrier, but are commonly effluxed back into the blood by transporters that are expressed at the luminal membrane, notably P-glycoprotein (P-gp). It has also been shown that amyloid-β (Aβ), a key player in Alzheimer's disease, is a P-gp substrate. We demonstrate that P-gp levels and function are upregulated upon activation by the vitamin D receptor (VDR) via its natural ligand 1α,25-dihydroxyvitamin D

Department dc:contributor.department

Pharmaceutical Sciences

Year dc:date.issued

2014

Author dc:creator

• Durk, Robert Matthew

Advisor dc:contributor.advisor

• Pang, Kim-Ching Sandy

• blood-brain barrier
• P-glycoprotein
• regulation
• vitamin D receptor

Handle dc:identifier.uri

http://hdl.handle.net/1807/67621

OAI identifier oai:identifier

oai:utoronto.scholaris.ca:1807/67621