Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"P-glycoprotein"”.
-
Regulation of P-glycoprotein at the Blood-Brain Barrier
… function is the ATP-driven efflux transporter, P-glycoprotein (P-gp) that denies CNS entry to a myriad of therapeutics. Thus, a better understanding of the mechanisms regulating P-gp expression and transport function might provide new strategies to improve drug delivery to the brain and increase …
-
Placental P-glycoprotein: Role in disposition of medications administered during pregnancy
… activity of the placental efflux transporter P-glycoprotein (P-gp) and its role in regulating the placental distribution of medications used during pregnancy. P-gp expression and transport activity were defined in brush border membrane vesicles prepared from human placenta of various gestational …
-
Characterization of P-glycoprotein expression as a multixenobiotic resistance mechanism in fish
Transmembrane P-glycoproteins (P-gps) are responsible for multidrug resistance (MDR) phenotypes in tumor cell lines. P-glycoproteins function as energy dependent efflux flippases that prevent the cellular accumulation of a wide variety of compounds. We characterized P-gp expression in populations …
-
A P-glycoprotein-like mechanism in the nicotine-resistant insect, Manduca sexta.
… overexpression of a membrane protein called P-glycoprotein. Since its initial discovery in tumor cells, P-glycoprotein-like molecules have been found to transport a wide range of substrates in organisms from microorganisms to humans. To test the hypothesis that a P-glycoprotein-like mechanism …
-
P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
The ABC transporter P-glycoprotein (Pgp) and membrane permeability are determinant factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of …
-
NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein
… of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at the blood-brain barrier (BBB). Increased P-gp functional expression was associated with a significant reduction in CNS uptake of morphine and, subsequently, reduced morphine analgesic efficacy. …
-
Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
… of expression of alkaline phosphatase and P-glycoprotein and a greater cellular uptake of Gly-1.-Pro than those of passage number <40 from the American Type Tissue Culture collection. High P-gp expressing Caco-2 cells have been developed through stepwise selection of the cells with …
-
Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier
… are expressed at the luminal membrane, notably P-glycoprotein (P-gp). It has also been shown that amyloid-β (Aβ), a key player in Alzheimer's disease, is a P-gp substrate. We demonstrate that P-gp levels and function are upregulated upon activation by the vitamin D receptor (VDR) via its natural …
-
In vitro Zellkulturmodelle der Blut-Hirn-Schranke zur Untersuchung der Permeation und P-Glycoprotein-Interaktion von Arzneistoffen
… Untersuchung von Arzneistoff-Interaktionen mit P-Glycoprotein (P-gp). Die Zellisolierung erfolgte nach einer rein enzymatischen Methode aus Schweinehirn. Die Zellen zeigten gutes Wachstum und bildeten konfluente Monolayer, was mit Aktinfärbungen belegt wurde. Immunfärbungen des …
-
Mechanism of sarcoplasmic reticulum Ca-ATPase and multidrug resistance P-glycoprotein probed by Pi-HOH oxygen exchange
Bibliography: leaves 135-146.
-
Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains
… malaria parasite Plasmodium falciparum, the P-glycoprotein homologue1 (Pgh1), was quantified on food vacuoles, the site of action of chloroquine. Chloroquine susceptibility was determined in 8 different P. falciparum strains. Food vacuoles were isolated from trophozoites of two …
-
Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
Multidrug efflux pump P-glycoprotein (P-gp) has been the subject of significant research interest since the discovery of the protein in multi-drug resistant cancer cells 40 years ago. Overexpression of P-gp can confer resistance to a broad range of structurally and functionally distinct drugs. The …
-
Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
Multidrug efflux pump P-glycoprotein (P-gp) has been the subject of significant research interest since the discovery of the protein in multi-drug resistant cancer cells 40 years ago. Overexpression of P-gp can confer resistance to a broad range of structurally and functionally distinct drugs. The …
-
The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… (ATP)-binding cassette (ABC) transporters P-glycoprotein (Pgp) and multidrug resistance associated protein 1 (MRP1), which efflux many drugs used in neuroblastoma therapy, has been implicated in poor outcome in neuroblastoma. Therefore, the purpose of our studies was to determine the role of …
-
Investigating the modulation of oral drug absorption using in vitro models
… using calcein-AM to show the inhibition of p-glycoprotein activity. There was no significant change due to the presence of mannitol but there was in the presence of clyclosporin A (p<0.01). Incubating the cells with the test solution for 30 minutes before the addition of the ester resulted in …
-
Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… cassette drug efflux transporters i.e., P-glycoprotein and breast cancer resistance protein, have been previously shown to efflux antiretroviral drugs at the level of blood-brain barrier (Dallas, et al., 2004a;Lee, et al., 2007;Lee and Bendayan, 2004;Ronaldson, et al., 2004;Ronaldson, et …
-
Identification and Development of Novel Compounds for the Treatment of Human Cancers
… the G-quadruplex of the c-Myc promoter and p-glycoprotein, have been investigated. By developing such compounds, improvements in treatment efficacy is anticipated with an aspiration for decreased mortality attributable to cancer.Formation of DNA secondary structures, such as the G-quadruplex, …
-
In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds with special reference to multidrug resistance and cancer chemotherapy
… Immunoprecipitation revealed the presence of P-glycoprotein in the EMT-6/R cell line but not in any detectable amounts in the parent cell line. No significant difference in the glutathione content was observed although a significant increase in glutathione-S-transferase (GST) activity was …
-
The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… survival. It is often overexpressed in TNBC. P-glycoprotein (P-gp) is a transmembrane glycoprotein responsible for active transport of substances across the cell membrane out of a cell. It functions as an efflux pump and is overexpressed in many cancer cells. The altered expression of both EGFR …
-
Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
… pump inhibitors, proton gradient dissipaters, P-glycoprotein ATPase- and drug transport-inhibitors, weak bases, and structural analogues of chloroquine were used to examine the driving force of chloroquine accumulation in the isolated food vacuole. A pH gradient between the vacuole and cytoplasm …
Page 1 of 4