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University of Tennessee Health Science Center
Identification of Novel CYP2E1 Inhibitor to Investigate Cellular and Exosomal CYP2E1-Mediated Toxicity
Abstract
dc:description.abstract<p>Cytochrome P450 2E1 (CYP2E1)-mediated hepatic and extra-hepatic toxicity is of significant clinical importance. Diallyl sulfide (DAS) has been shown to prevent xenobiotics such as alcohol- (ALC/ETH), acetaminophen- (APAP) induced toxicity and disease (e.g. HIV-1) pathogenesis. DAS imparts its beneficial effect by inhibiting CYP2E1-mediated metabolism of xenobiotics, especially at high concentration. However, DAS also causes toxicity at relatively high dosages and with long exposure times. The objective of the first project was to find potent DAS analogs which can replace DAS as a research tool or as potential adjuvant therapy in CYP2E1-mediated pathologies.</p>
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Pharmaceutical Sciences
- Year dc:date.available
- 2019
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Rahman, Mohammad Arifur
- Contributors dc:contributor
-
- Santosh Kumar, Ph.D.
Subjects
dc:subject × 8Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.uthsc.edu/dissertations/482
- OAI identifier oai:identifier
- oai:dc.uthsc.edu:dissertations-1482