Diffusion Tensor Imaging in Pediatric Brain Tumor Patients

<p>In this dissertation, we outline our efforts to introduce an advanced MRI imaging technique called Diffusion Tensor Imaging (DTI) to the pediatric brain tumor population. We discuss the theory and application of DTI as it was performed in a series of translational investigations at St. Jude Children’s Research Hospital. We present evidence of how the introduction of this technique impacted diagnosis, and treatment. And finally, we demonstrate how DTI was used to investigate cognitive morbidities associated with cancer treatment and how this research provided insight into the underlying pathophysiology involved in the development of these treatment sequela. </p> <p>This research has generated important insights into the fundamental causes of neuroanatomical and cognitive deficits associated with cancer and cancer therapy. The use of DTI has permitted us to identify potential targets for improved radiological and surgical techniques as well as targets for pharmacological and behavioral interventions that might improve cognitive function in cancer survivors. The discoveries here afford us an opportunity to reduce the negative effects of cancer therapy on patients treated in the future while maintaining successful survival rates. </p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biomedical Engineering and Imaging

Year dc:date.available

2009

Author dc:creator

• Phillips, Nicholas S.

Contributors dc:contributor

• Robert J. Ogg Ph.D.

• DTI
• imaging
• pediatrics
• brain tumors
• cancer
• MRI
• Analytical, Diagnostic and Therapeutic Techniques and Equipment
• Diagnosis
• Medicine and Health Sciences

Repository record dc:identifier

https://dc.uthsc.edu/dissertations/201

OAI identifier oai:identifier

oai:dc.uthsc.edu:dissertations-1204