University of South Carolina
Phylogenetic Analysis Suggests Horizontal Gene Transfer Event Within the Mitis Group Within the Genus Streptococcus Involving L-Amino Oxidase In Streptococcus Oligofermentans
Abstract
dc:description.abstract<p>This phylogenetic study was undertaken in order to provide further elucidation to evolutionary relationships within the genus streptococcus. The inhibition by Streptococcus oligofermentans of Streptococcus mutans is of particular interest. A comprehensive mechanism for this inhibition has been previously resolved in vitro and isolated to L-amino acid oxidase (LAAO) within S. oligofermentans which produces high levels of H2O2 through the metabolism of seven L-amino. Phylogenetic analysis of coded amino acid (AA) sequences within 20 enterococci present insights into possible methods for control of the etologic factors of dental caries. Analysis of 10 amino acid sequences from 19 Streptococcus species and Lactococcus lactis using pairwise between-species distances and phylogenies based on maximum likelihood (ML) suggest possible horizontal gene transfer (HGT) of L-amino oxidase (lox) conferring inhibitory properties against S. mutans to S. oligofermentans. </p>
Degree
thesis:*- Name thesis:degree_name
- M.S.
- Level thesis:degree_level
- Campus Access Thesis
- Discipline thesis:degree_discipline
- Biological Sciences
- Year
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Boggs, Joseph Marc
- Contributors dc:contributor
-
- Austin L Hughes
Subjects
dc:subject × 9Rights
dc:rights- Statement dc:rights
-
- © 2011, Joseph Marc Boggs
Identifiers
dc:identifier.*- Repository record dc:identifier
- https://scholarcommons.sc.edu/etd/487
- OAI identifier oai:identifier
- oai:scholarcommons.sc.edu:etd-1488