Role of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamster

The objective of this study was to verify whether the response to ET-1 in the intact aorta of a normal hamster is different than that of a CMP hamster and, if so, whether the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 receptors (ET[indice inférieur A] and/or ET[indice inférieur B]) in the vascular endothelium and vascular smooth muscle cells (VSMCs) undergoes changes during the development of CMP in the hamster. Our results suggest that there is a difference in the responsiveness to ET-1 stimulation in aortas from CMP hamsters compared to those from normal hamsters. This difference in responsiveness to ET-1 could be due, in part, to an increase in ET[indice inférieur B] receptor density in vascular endothelial cells. This may result in an increase in the synthesis and release of NO that, in turn, produces a large relaxation and opposes the vasoconstrictive effect of ET-1."--Résumé abrégé par UMI.

Name thesis:degree_name

M. Sc.

Level thesis:degree_level

Maîtrise

Discipline thesis:degree_discipline

Biologie cellulaire

Grantor dc:publisher

Université de Sherbrooke

Year dc:date.issued

2004

Author dc:creator

• Al-Khoury, Johny Jeryes

Advisor dc:contributor.advisor

• Bkaily, Ghassan

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/11143/3357

OAI identifier oai:identifier

oai:usherbrooke.scholaris.ca:11143/3357