Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"ET-1"”.
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L'activité chymase de la mMCP-4 est impliquée dans la conversion de la BIG-ET-1 EN ET-1 (1-31) chez la souris in vitro
L'endothéline (ET-1) est un puissant vasoconstricteur constitué de 21 acides aminés et de deux ponts disulfures intramoléculaires qui provient d'un précurseur prépro-ET, composé de 212 acides aminés.L'hydrolyse de ce précurseur par des peptidases conduit à la Big-ET-1, peptide de 38 acides aminés. …
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Role of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamster
The objective of this study was to verify whether the response to ET-1 in the intact aorta of a normal hamster is different than that of a CMP hamster and, if so, whether the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… Recent evidences suggest that factors secreted by activated astrocytes might contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide which is strongly up-regulated in reactive astrocytes under different pathological conditions. We show that ET-1 is abundantly …
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Studies of the mammalian ovarian endothelin system
In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… feedback that antagonizes the effects of stretch-activated cation channels. Persistent activation of ICl,swell has been observed in multiple models of cardiovascular diseases. Previously we showed that angiotensin II (AngII) signaling and reactive oxygen species (ROS) produced by NADPH …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
<p>The purpose of this study was to determine whether Endothelin-1 (ET-1) induced cellular responses in bovine corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… pain, there is still concern regarding the safety of using analgesics and anesthetics in infants. This thesis has developed an animal model using Endothelin-1 (ET-1), a peptide that is involved in vaso-occlusive crisis, to investigate the cellular and molecule mechanisms by which painful VOEs …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that …
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Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis
… response to aeroallergens, and endothelin (ET)-1 is a potential mediator of airway obstruction. The goal of this dissertation was to describe and explore the interaction of aeroallergens triggering inflammation and T lymphocytes cytokine profile with the recruitment and activation of …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… of premigratory neural crest cells or targeted deletion of genes required for their proliferation, migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… of premigratory neural crest cells or targeted deletion of genes required for their proliferation, migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to …
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… the kidney. Myoglobin stimulated endothelin-1 (ET-1) production in proximal tubular cells, an effect driven by NADPH oxidase-dependent oxyradical generation. Rats subjected to glycerol-induced rhabdomyolysis also exhibited ROS-dependent ET-1 production. Vasoactive ET-1 is generated by ET …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned medium (ACM) inhibited the …
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… levels of catecholamines and endothelin-1 (ET-1), each of which affects the atrial L-type calcium current (ICaL) and consequently action potentials. Hypotheses: ET-1 modulates the effects of isoproterenol (ISO) on ICaL and action potentials in human atrial myocytes. Methods: Atrial myocytes …
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A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
… (CIN) is a severe complication that can sometimes affect the kidneys of patients following angiographic procedures that involve the administration of iodinated contrast medium (CM) to aid visualisation of blood vessels in medical imaging. CIN represents around 12% of all hospital acquired …
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Einfluss von Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Kardiomyozyten aus gesundem und terminal insuffizientem Myokard
… enthalten oder stehen in klinischer Erprobung (ETA-Rezeptorenblocker). Die vorliegende Arbeit untersuchte den Einflussvon Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Myozyten aus Vorhof- sowie gesundem und terminal insuffizientem Ventrikelmyokard. Darüber hinaus sollte die …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… positive recycling endosomes. Endothelin-1 (ET-1), a vasoconstrictor, induces contraction of myocytes. ET-1 inhibits BK channel but mechanisms are not fully understood. It is unclear that vasoconstrictors regulate the cellular distribution of BK channels. Furthermore, BK channels are involved …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… results of intercellular communication between melanocytes and keratinocytes for each of these cell types. I characterized the transcriptomes of human melanocytes and keratinocytes that were freshly derived from human tissue in Chapter 2. These data served as a reference for comparison …
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Towards a reproducible model for subcortical capsular strokes
… for use in stroke damage to the PLIC: (1) a method of infusing an endogenous vasoconstrictor, endothelin-1 (ET-1), into the internal capsule and (2) a model of photothrombotic stroke that uses a photosensitive dye to cause ischemic-like damage and modified to induce focal lesions to …
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The relationship between circulating biomarkers of nitric oxide and endothelin-1 and hemodynamic function in obstructive sleep apnea
… of the vasoconstrictor endothelin-1 (ET-1) and removal of the vasodilator nitric oxide (NO). Means to reduce the effects of ET-1 and increase synthesis of NO may have beneficial effects on the cardiovascular co-morbidity commonly associated with OSA. OBJECTIVES: The major aim of this …
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