A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments

<p>Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (¹O₂) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H₂O₂) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.</p>

Name thesis:degree_name

Master of Science - Natural Sciences

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Chemistry and Biochemistry

Year dc:date.available

2021

Author dc:creator

• Ali, Aqeeb

Contributors dc:contributor

• Dr. Matibur Zamadar
• Dr. Michele Harris
• Dr. Xiaozhen Han

• Photodynamic Therapy
• TMPyP
• 1
• 5-DHN
• Fe(III)
• Cancer
• Aerobic
• Anaerobic
• Hydrogen Peroxide
• Organic Chemistry

Repository record dc:identifier

https://scholarworks.sfasu.edu/etds/374

OAI identifier oai:identifier

oai:scholarworks.sfasu.edu:etds-1398