Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (1O2) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H2O2) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.
","abstract_html":"<p>Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (<sup>1</sup>O<sub>2</sub>) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.</p>","abstract_has_math":false,"creators":["Ali, Aqeeb"],"institution":null,"degree_name":"Master of Science - Natural Sciences","degree_level":"Thesis","degree_discipline":"Chemistry and Biochemistry","degree_department":null,"school":null,"contributors":["Dr. Matibur Zamadar","Dr. Michele Harris","Dr. Xiaozhen Han"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-05-01T07:00:00Z","date_published":"2021-05-01T07:00:00Z","updated_at":"2026-07-24T04:30:30Z","subjects":["Photodynamic Therapy","TMPyP","1","5-DHN","Fe(III)","Cancer","Aerobic","Anaerobic","Hydrogen Peroxide","Organic Chemistry"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarworks.sfasu.edu/etds/374","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dr. Matibur Zamadar","Dr. Michele Harris","Dr. Xiaozhen Han"]},{"key":"dc:creator","label":"Author","values":["Ali, Aqeeb"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2021-05-05T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry and Biochemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science - Natural Sciences"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Photodynamic Therapy","TMPyP","1","5-DHN","Fe(III)","Cancer","Aerobic","Anaerobic","Hydrogen Peroxide","Organic Chemistry"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarworks.sfasu.edu/etds/374"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (1O2) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H2O2) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.
"]},{"key":"dc:title","label":"Title","values":["A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments"]}]}],"canonical_facts":{"dc:contributor":["Dr. Matibur Zamadar","Dr. Michele Harris","Dr. Xiaozhen Han"],"dc:creator":["Ali, Aqeeb"],"dc:date.available":["2021-05-05T07:00:00Z"],"dc:description.abstract":["Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (1O2) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H2O2) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.
"],"dc:identifier":["https://scholarworks.sfasu.edu/etds/374"],"dc:subject":["Photodynamic Therapy","TMPyP","1","5-DHN","Fe(III)","Cancer","Aerobic","Anaerobic","Hydrogen Peroxide","Organic Chemistry"],"dc:title":["A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments"],"thesis:degree_discipline":["Chemistry and Biochemistry"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science - Natural Sciences"]},"updated_at":"2026-07-24T04:30:30Z"}