Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells

In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I or II (IGF-I or IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells in culture, and to determine the possible site(s) of action of these agents on steroidogenesis. Both IGF-I and IGF-II increased (P $

Name thesis:degree_name

Doctor of Philosophy (Ph.D.)

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Animal and Poultry Science

Grantor

University of Saskatchewan

Year dc:date.issued

1996

Author dc:creator

• Xu, Yongping

Committee member dc:contributor.committeemember

• Thacker, Philip A.

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/10388/etd-10202004-235736

OAI identifier oai:identifier

oai:harvest.usask.ca:10388/etd-10202004-235736