{"id":{"repo_id":"sask","oai_identifier":"oai:harvest.usask.ca:10388/etd-10202004-235736"},"canonical_url":"https://search.dev.ndltd.org/etd/sask/oai:harvest.usask.ca:10388/etd-10202004-235736","repository":{"repo_id":"sask","name":"University of Saskatchewan","base_url":"https://harvest.usask.ca/server/oai/request"},"display":{"title":"Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells","abstract":"In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I or II (IGF-I or IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells in culture, and to determine the possible site(s) of action of these agents on steroidogenesis. Both IGF-I and IGF-II increased (P $","abstract_html":"In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I or II (IGF-I or IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells in culture, and to determine the possible site(s) of action of these agents on steroidogenesis. Both IGF-I and IGF-II increased (P $","abstract_has_math":false,"creators":["Xu, Yongping"],"institution":"University of Saskatchewan","degree_name":"Doctor of Philosophy (Ph.D.)","degree_level":"Doctoral","degree_discipline":"Animal and Poultry Science","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":["Thacker, Philip A."],"year":1996,"date_issued":"1996-01-01","date_published":"1996-01-01","updated_at":"2026-07-24T04:27:18Z","subjects":[],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10388/etd-10202004-235736","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Thacker, Philip A."]},{"key":"dc:creator","label":"Author","values":["Xu, Yongping"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2004-10-20T23:57:36Z","2013-01-04T05:01:49Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["1996-01-01T08:00:00Z","2013-01-04T05:01:49Z"]},{"key":"dc:date.issued","label":"Date","values":["1996-01-01"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal and Poultry Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (Ph.D.)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Saskatchewan"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10388/etd-10202004-235736"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I or II (IGF-I or IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells in culture, and to determine the possible site(s) of action of these agents on steroidogenesis. Both IGF-I and IGF-II increased (P $"]},{"key":"dc:title","label":"Title","values":["Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells"]}]}],"canonical_facts":{"dc:contributor.committeemember":["Thacker, Philip A."],"dc:creator":["Xu, Yongping"],"dc:date.accessioned":["2004-10-20T23:57:36Z","2013-01-04T05:01:49Z"],"dc:date.available":["1996-01-01T08:00:00Z","2013-01-04T05:01:49Z"],"dc:date.issued":["1996-01-01"],"dc:description.abstract":["In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I or II (IGF-I or IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells in culture, and to determine the possible site(s) of action of these agents on steroidogenesis. Both IGF-I and IGF-II increased (P $"],"dc:identifier.uri":["https://hdl.handle.net/10388/etd-10202004-235736"],"dc:language.iso":["en_US"],"dc:title":["Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells"],"thesis:degree_discipline":["Animal and Poultry Science"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Doctor of Philosophy (Ph.D.)"],"thesis:institution_name":["University of Saskatchewan"]},"updated_at":"2026-07-24T04:27:18Z"}