U. of Salford
Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics
Abstract
dc:description.abstractDAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients.
Degree
thesis:*- Level dc:type.qualificationlevel
- Master's Level (Level 7)
- Year dc:date.issued
- 2021
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Dobiecki-Davies, J
Rights
- Language dc:language
- en
Identifiers
dc:identifier.*- Identifier
- oai:salford-repository.worktribe.com:1337324
- OAI identifier oai:identifier
- oai:salford-repository.worktribe.com:1337324