{"id":{"repo_id":"salford","oai_identifier":"oai:salford-repository.worktribe.com:1337324"},"canonical_url":"https://search.dev.ndltd.org/etd/salford/oai:salford-repository.worktribe.com:1337324","repository":{"repo_id":"salford","name":"U. of Salford","base_url":"https://salford-repository.worktribe.com/oaiprovider"},"display":{"title":"Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics","abstract":"DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients.","abstract_html":"DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients.","abstract_has_math":false,"creators":["Dobiecki-Davies, J"],"institution":null,"degree_name":null,"degree_level":"Master's Level (Level 7)","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021","date_published":"2021","updated_at":"2026-07-24T04:26:09Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:salford-repository.worktribe.com:1337324"],"render_values":[{"text":"oai:salford-repository.worktribe.com:1337324","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["Kidscan"]},{"key":"dc:creator","label":"Author","values":["Dobiecki-Davies, J"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-03-31"]},{"key":"dc:date.issued","label":"Date","values":["2021"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://salford-repository.worktribe.com/output/1337324"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Master's Level (Level 7)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:salford-repository.worktribe.com:1337324"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://salford-repository.worktribe.com/file/1337324/1/Joe%20Dobiecki-Davies%20MSc%20final%20copy.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients."]},{"key":"dc:title","label":"Title","values":["Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics"]}]}],"canonical_facts":{"dc:contributor.sponsor":["Kidscan"],"dc:creator":["Dobiecki-Davies, J"],"dc:date":["2021-03-31"],"dc:date.issued":["2021"],"dc:description.abstract":["DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients."],"dc:identifier":["oai:salford-repository.worktribe.com:1337324"],"dc:identifier.uri":["https://salford-repository.worktribe.com/file/1337324/1/Joe%20Dobiecki-Davies%20MSc%20final%20copy.pdf"],"dc:language":["en"],"dc:relation.isreferencedby":["https://salford-repository.worktribe.com/output/1337324"],"dc:title":["Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Master's Level (Level 7)"]},"updated_at":"2026-07-24T04:26:09Z"}