Effect of creatine monohydrate supplementation in aging adults with type II diabetes

Sarcopenia generally refers to the age-related reduction in muscle strength and physical performance, with greater decreases found in aging adults with type II diabetes (T2D). Supplementing with creatine, a nitrogen-containing compound formed from reactions involving the amino acids arginine, glycine and methionine, is an intervention which have been shown to increase muscle strength, endurance and physical performance in healthy aging adults. Further, creatine supplementation has been shown to influence glucose metabolism in individuals with T2D. However, the effects of creatine supplementation in aging adults with T2D in unknown. Therefore, the purpose of this study was to examine the effects of creatine supplementation on measures of blood glucose, muscle strength, endurance and tasks of physical performance in aging adults with T2D. Using a double-blind, repeated measures design, participants were randomized to supplement with creatine monohydrate (CR: n = 4; 71 ± 7 years, 94.3 ± 13.9 kg, 165.2 ± 6.0 cm; 0.3 g·kg -1·day -1) or placebo (PLA: n = 3; 74 ± 2 years, 95.2 ± 7.3 kg, 159.3 ± 9.5cm; 0.3 g·kg -1·day -1 maltodextrin) for seven consecutive days. Prior to and following supplementation, variables measured were fasting blood glucose, muscle strength (1-repetition maximum leg press, chest press, hand-grip), muscle endurance (leg press and chest press; maximal number of repetitions performed at 50% baseline 1-repetittion maximum), and tests of physical performance (6-minute walk test, sit-to-stand chair test). Results showed that both groups experienced similar changes in all measures over time. In conclusion, in this preliminary investigation, creatine supplementation had no effect on blood glucose or measures of muscle strength, endurance and physical performance in aging adults with T2D. Key words: sarcopenia, blood glucose, strength, physical performance

Name thesis:degree_name

Master of Science (MSc)

Level thesis:degree_level

Master's

Discipline thesis:degree_discipline

Kinesiology and Health Studies

Grantor dc:publisher

Faculty of Graduate Studies and Research, University of Regina

Year dc:date.issued

2023

Author dc:creator

• Bailie, Robert David

Advisor dc:contributor.advisor

• Candow, Darren

Committee members dc:contributor.committeemember

• Totosy de Zepetnek, Julia
• Little, Jonathan

• Sarcopenia
• Blood glucose
• Strength
• Physical performance

Language dc:language.iso

en

DOI

https://doi.org/10.82465/4857

OAI identifier oai:identifier

oai:uregina.scholaris.ca:10294/16095