Adsorptive Immobilisierung von Kollagen Typ I an Titanoxidoberflächen

Titanium and titanium alloys are frequently used for implants in bone contact. In some cases (diabetis, osteoporosis) there are requirements for improved osseointegration. Initial reactions after surgery show an important influence on the long time stability of the implants. Newer studies focus on the surface composition of the implants in particular the modification with biological components. Collagen is the main component of bone and is therefore an interesting substance for the base modification of titanium implants. The aim of the work was to investigate the adsorptive immobilisation of collagen type I on titanium surfaces. The influence of different adsorption parameters was studied. Several modified surfaces were characterized in matters of immobilized collagen amount, stability, change of conformation and influence on cell behavior.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2004

Author dc:creator

• Wolf-Brandstetter, Cornelia

Contributors dc:contributor

• van Pée, Karl-Heinz
• Scharnweber, Dieter
• Heckmann, Klaus

• Implantate
• Kollagen
• Oberflächenmodifizierung
• Proteinadsorption
• Titan
• collagen
• implants
• protein adsorption
• surface modification
• titanium